Evidence map›Paper›PMID 41496746›Full record

ArticleJournal of hepatocellular carcinoma2025

Research Hotspots of Traditional Chinese Medicine for Liver Cancer in the Future Directions: A Bibliometric Analysis.

Zheng Liu, Tai Zhang, Chun-Miao Xue, Wan-Tong Zhang, Bao-Chen Zhu, Guo-Dong Hua

Abstract read
In one paragraph

Article in Journal of hepatocellular carcinoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zheng LiuDepartment of Pharmacy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, People's Republic of China.ORCID 0009-0001-2358-5596
Tai ZhangDepartment of Pharmacy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Chun-Miao XueDepartment of Pharmacy, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Wan-Tong ZhangDepartment of Cardiovascular Medicine, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Bao-Chen ZhuDepartment of Pharmacy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Guo-Dong HuaDepartment of Pharmacy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Traditional Chinese medicine (TCM) demonstrates growing potential in liver cancer management, yet a comprehensive overview mapping the intellectual landscape and evolving trends of this field is lacking. This study aims to fill this gap by conducting a systematic bibliometric analysis of TCM for liver cancer research over the past decade. Methods: We performed a bibliometric analysis of publications related to TCM and liver cancer retrieved from major databases including China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and Web of Science. The search timeframe spanned from February 14, 2015, to the search date (February 14, 2025). The literature was analyzed using scientific mapping tools, such as CiteSpace, Origin 2024, R, and VOSviewer, to identify publication trends, collaborative networks, research hotspots, and frontier topics. Results: The analysis reveals a steadily growing and globally engaged field, with China being the dominant contributor. While core research teams are emerging, international and cross-regional collaborations remain limited. A clear thematic divergence exists: international literature primarily focuses on exploring the pharmacological mechanisms of TCM compounds, whereas Chinese-language studies place greater emphasis on clinical applications, medication rules, data mining, and TCM syndrome differentiation. Key emerging research frontiers include mechanisms of action, omics technologies, bioinformatics technology, network pharmacology and molecular docking, TCM syndrome research, TCM theory innovation and exploration, TCM nanodelivery, data mining, and deep learning. Conclusion: This bibliometric review provides a comprehensive landscape of TCM research for liver cancer, highlighting its dynamic growth and the complementary nature of mechanistic and clinical research streams. The findings underscore the necessity for enhanced international collaboration to bridge existing gaps and foster integrated, innovative approaches for advancing TCM in oncology.

Indexed as

bibliometricsChinese herbal medicineliver cancermechanismstraditional Chinese medicinevisual analysis

Identifiers

PMID41496746
PMCPMC12766475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.