Evidence map›Paper›PMID 41496723›Full record

ReviewChemical Society reviews2026

Chemical fluorophores for fluorescence lifetime imaging.

Clarissa Lim, Deborah Seah, Marc Vendrell

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.Angewandte Chemie (International ed. in English) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Clarissa LimSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637371, Singapore.
Deborah SeahCentre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK. marc.vendrell@ed.ac.uk.
Marc VendrellCentre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK. marc.vendrell@ed.ac.uk.ORCID http://orcid.org/0000-0002-5392-9740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescence lifetime imaging has emerged as a promising modality to extract molecular information from biological systems, providing detailed and semi-quantitative characterisation of subcellular microenvironments. Fluorescence lifetime measurements offer robust insights into biological processes as they are less dependent on concentration and excitation power than intensity-based measurements. However, fluorescence lifetime imaging suffers from a paucity of fluorophores with wide dynamic ranges of lifetimes and responsiveness to biostimuli. This shortcoming has prompted the design of new chemical strategies to tailor the optical properties of organic fluorophores and their application in multiplexed live-cell imaging for the visualisation of molecular and cellular interactions. This Review article covers advances - primarily from the last 5 years - in the chemical design of fluorescence lifetime probes that combine optical reporters and targeting groups (

Indexed as

Fluorescent DyesOptical ImagingAnimalsHumansFluorescent Dyes

Identifiers

PMID41496723
PMCPMC12775908

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.