Evidence map›Paper›PMID 41496622›Full record

ArticleCurrent topics in medicinal chemistry2025

Diazinon-induced Cognitive Impairment: Alternations in Amyloid Precursor Proteins, and TNF-α Expression in the Hippocampus of Adult Rats.

Mehdi Sarailoo, Salva Afshari, Vahid Asghariazar, Mehdi Vosoughi Niri, Elham Safarzadeh, Masoomeh Dadkhah

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Article in Current topics in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mehdi SarailooStudents Research Committee, School of Public Health, Ardabil University of Medical Sciences, Ardabil, Iran.
Salva AfshariStudents Research Committee, Pharmacy School, Ardabil University of Medical Sciences, Ardabil, Iran.
Vahid AsghariazarCancer Immunology and Immunotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Mehdi Vosoughi NiriDepartment of Environmental Health, School of Health, Social Determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Elham SafarzadehCancer Immunology and Immunotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Masoomeh DadkhahPharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.

Funding

Ardabil University of Medical Sciences, Ardabil, Iran 1004069
6 · The paper itself

Abstract

backgroundOrganophosphate pesticides such as diazinon (DZN) are involved in developing psychological symptoms and memory deficits, but their effects on the amyloid precursor proteins (APP) gene expression remain unclear. MATERIALS AND

methodsFollowing low-level oral exposure to the DZN (2 mg/kg), we used novel object recognition, open field, and elevated plus-mazes (EPM) to assess memory and anxiety-like behaviors in rats. We also evaluated alteration in the levels of tumor necrosis factor (TNF-α), amyloid precursor protein (APP), APP-like protein-2 (APLP2), and amyloid-β (Aβ) via western blotting and ELISA. Real-time quantitative PCR was performed to evaluate the expression of the related genes in the hippocampus.

resultsThe findings demonstrated that whereas DZN exposure boosted anxiety-like behaviors at any exposure level, only prolonged exposure (12 weeks) resulted in memory impairment. The study also found that the hippocampal expression of APP and APLP2 decreased after 12 weeks of exposure but not after 5 days. Additionally, Aβ increased after long-lasting exposure to DZN, indicating the APP contribution to AD pathologies. The TNF-α gene was up-regulated following 5 days of exposure, but 12 weeks had no effect.

conclusionOur finding demonstrates that long-lasting exposure to low levels of DZN in adulthood stimulates APP degradation, possibly contributing to poor cognitive outcomes.

Indexed as

Amyloid beta-Protein PrecursorCognitive DysfunctionDiazinonHippocampusTumor Necrosis Factor-alphaAnimalsMaleRatsRats, Sprague-DawleyRats, WistarAmyloid beta-Protein PrecursorDiazinonTumor Necrosis Factor-alphaAmyloid beta.Amyloid precursor proteinsAnxiety-like behaviorsDiazinonHippocampusNovel object recognition memoryTNF-α

Identifiers

PMID41496622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.