Evidence map›Paper›PMID 41496485›Full record

ArticleEarly intervention in psychiatry2026

Preliminary Findings From an Augmented Reality (AR) App Delivering Recovery-Oriented Cognitive Therapy for Negative Symptoms in Schizophrenia.

Sunny X Tang, Moein Foroughi, Aaron P Brinen, Michael L Birnbaum, Sarah A Berretta, Leily M Behbehani, John M Kane, Edward Yoon, William F Cronin

Registry-linked trialAbstract read
In one paragraph

Article in Early intervention in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07593456 (Investigating a Gamified NegatIve-symptom Therapeutic Based on Evidence-based Cognitive Therapy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07593456 nanot yet recruitingnot on this mapstarted 2027, after this paper: background citation

Investigating a Gamified NegatIve-symptom Therapeutic Based on Evidence-based Cognitive Therapy (IGNITE)

TypeinterventionalSponsorNorth Shore Therapeutics, Inc.Ran2027 to 2028Enrolled30ConditionsSchizophrenia / Schizoaffective DisorderArmsNST-SPARK
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sunny X TangNorth Shore Therapeutics, Inc., Rochester, Minnesota, USA.
Moein ForoughiZucker Hillside Hospital, Northwell Health, Glen Oaks, New York, USA.
Aaron P BrinenNorth Shore Therapeutics, Inc., Rochester, Minnesota, USA.
Michael L BirnbaumNorth Shore Therapeutics, Inc., Rochester, Minnesota, USA.
Sarah A BerrettaNorth Shore Therapeutics, Inc., Rochester, Minnesota, USA.
Leily M BehbehaniNorth Shore Therapeutics, Inc., Rochester, Minnesota, USA.
John M KaneNorth Shore Therapeutics, Inc., Rochester, Minnesota, USA.
Edward YoonNorth Shore Therapeutics, Inc., Rochester, Minnesota, USA.
William F CroninNorth Shore Therapeutics, Inc., Rochester, Minnesota, USA.ORCID https://orcid.org/0009-0004-4220-6899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNST-SPARK is a novel digital therapeutic targeting negative symptoms in schizophrenia spectrum disorders (SSD). It is a smartphone application delivering recovery-oriented cognitive therapy (CT-R), via gamified augmented reality (AR) experiences. The primary objective was to determine the acceptability and feasibility of a single-session prototype. Secondary objectives were to generate descriptive findings for changes in defeatist beliefs, self-esteem and attitudes toward goal-oriented activities.

methodsTwenty participants with schizophrenia or schizoaffective disorder enrolled. Participants completed self-reports on the acceptability and feasibility of NST-SPARK v.1.5 and provided open-ended feedback. Self-report scales on defeatist beliefs, self-esteem and attitudes toward goal-oriented activities were completed before and after participants were introduced to NST-SPARK, and at 1-week follow-up.

resultsParticipants found NST-SPARK to be feasible and acceptable, with an average response of 'Agree', indicating that the intervention met with the participants' approval and seemed implementable. Almost all participants (19 of 20) used the app on their own prior to the 1-week follow up despite not being incentivised. We also observed changes in defeatist beliefs, self-esteem and attitudes toward goal attainment consistent with intended improvements in these targeted areas. Participants made substantive progress toward identified goals in 90% of cases. The most common positive feedback was appreciation that the app got them going, and the most common negative feedback pointed out technical aspects that did not function properly.

conclusionsThis preliminary, single-arm, unblinded study of a single-module prototype for NST-SPARK found that the approach is generally acceptable and feasible for people with SSD and negative symptoms.

Indexed as

Augmented RealityCognitive Behavioral TherapyMobile ApplicationsPsychotic DisordersSchizophreniaSchizophrenic PsychologyAdultFeasibility StudiesFemaleHumansMaleMiddle AgedPatient Acceptance of Health CareSelf ConceptTreatment Outcomeappaugmented realityCBTCT‐Rdigital healthnegative symptomsschizophrenia

Identifiers

PMID41496485
PMCPMC12775644

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.