Evidence map›Paper›PMID 41496304›Full record

ReviewMedical gas research2026

Comprehensive strategy of sonodynamic therapy and gas therapy on tumor treatment.

Lilin Zhao, Yaqi Zhang, Qian Huang, Ting Zhang

Abstract readReview
In one paragraph

Review in Medical gas research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lilin ZhaoDepartment of Ultrasound, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, Jiangsu Province, China.
Yaqi Zhang
Qian Huang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sonodynamic therapy has emerged as a novel non-invasive treatment for cancer with limited single effects. To achieve optimal therapeutic efficacy, sonodynamic therapy frequently needs to be combined with other therapeutic strategies. By exploiting the biological properties of specific gas molecules, gas therapy is an emerging tumor treatment that exerts direct or indirect inhibitory effects on tumor cells. This review systematically examines the rationales, methodologies, and outcomes of sonodynamic therapy and gas therapy combinatorial strategies for malignant tumors. There is a synergistic effect between sonodynamic therapy and gas therapy in tumor treatment. The ultrasound-induced cavitation enhances tissue permeability for improved gas delivery, while gas molecules concurrently sensitize sonodynamic reactions and ameliorate tumor hypoxia. The interaction significantly enhances the therapeutic effect of tumors. Moreover, the combination of sonodynamic therapy with other therapeutic modalities can significantly enhance the anti-tumor efficacy, improve the therapeutic precision and safety, while improve the tumor microenvironment. This combined treatment strategy can also reduce side effects and has a broad clinical application perspective.

Indexed as

GasesNeoplasmsUltrasonic TherapyAnimalsCombined Modality TherapyHumansTumor MicroenvironmentGasescombination therapygas therapyhypoxia modulationimmunotherapyphotodynamic therapyprecision oncologyreactive oxygen speciessonodynamic therapytumor microenvironmentultrasound-responsive material

Identifiers

PMID41496304
PMCPMC12935130

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.