Evidence map›Paper›PMID 41496264›Full record

ArticleCancer treatment and research communications2026

Yield of repeat gastric biopsies and Helicobacter pylori serological assessment in Lynch syndrome.

Jessica Vadaketh, Jake Konigsberg, Omar Elghawy, Kevin Dinh, Linda Zhu, Julia Youngman, Michaela Dungan, Marya Pulaski, Jessica M Long, Kole H Buckley and 1 more

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Article in Cancer treatment and research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jessica VadakethDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Jake KonigsbergDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Omar ElghawyDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Kevin DinhDivision of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Linda ZhuDivision of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Julia YoungmanDivision of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michaela DunganDivision of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Marya PulaskiBoston Medical Center, Division of Gastroenterology, Boston, MA, USA.
Jessica M LongDivision of Hematology-Oncology, Department of Medicine, Penn Medicine, Philadelphia, PA, USA; King Center for Lynch Syndrome, University of Pennsylvania, Philadelphia, PA, USA.
Kole H BuckleyDivision of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bryson W KatonaDivision of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; King Center for Lynch Syndrome, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: bryson.katona@pennmedicine.upenn.edu.

Funding

Postdoctoral Training Program in Genomic MedicineT32HG009495 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI Katherine L. Nathanson, Bogdan Pasaniuc · 2017 to 2026
$4.2M
NHGRI NIH HHS T32 HG009495
6 · The paper itself

Abstract

backgroundUpper gastrointestinal surveillance in Lynch syndrome (LS) remains an ongoing debate; some guidelines recommend upper endoscopy with non-targeted biopsies of the gastric antrum/body to detect Helicobacter pylori (HP) and/or gastric intestinal metaplasia (GIM). However, whether non-targeted gastric biopsies should be repeated on successive upper endoscopies remains uncertain. Therefore, we aimed to determine the yield of repeat non-targeted gastric antrum/body biopsies and assess the HP seropositivity of a LS cohort.

methodsClinical and pathology data were collected retrospectively from LS carriers who underwent upper endoscopy with non-targeted gastric biopsies. Plasma samples from a LS biobank were tested for HP IgG positivity.

resultsAmongst 683 LS carriers, there were 291 (43 %) with 1+, 145 (21 %) with 2+, and 45 (7 %) with 3+ upper endoscopies with non-targeted gastric antrum and body biopsies performed. The overall prevalence of GIM on those endoscopies was 8 % and the rate of HP was 3 %. Of individuals without GIM detected on the initial upper endoscopy, 4 % had GIM identified on their second, and 2 % had GIM identified on a third or greater upper endoscopy after having two prior upper endoscopies without GIM identified. There was no additional HP identified on subsequent endoscopies. Plasma HP IgG positivity amongst 257 LS carriers was 14 %.

conclusionsAmongst a LS cohort undergoing serial upper endoscopies, repeat gastric antrum/body biopsies yielded new cases of GIM, providing support for consideration of non-targeted gastric biopsies on all upper endoscopies performed in LS. Additionally, although endoscopic HP detection rates are low, HP exposure in LS is more common.

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisHelicobacter InfectionsHelicobacter pyloriStomachAdultBiopsyFemaleHumansMaleMetaplasiaMiddle AgedRetrospective StudiesGastric cancerGastric intestinal metaplasiaHelicobacter pyloriLynch syndromeSurveillanceUpper endoscopy

Identifiers

PMID41496264
PMCPMC13078353

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