Physiological oxygen levels reset K

Fan Yang, Ashia Wheeler-Crawford, Alan McIntyre, Giovanni E Mann, Joern R Steinert

Abstract read

In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fan YangSchool of Cardiovascular and Metabolic Medicine & Sciences, King's British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK.

Ashia Wheeler-CrawfordCentre for Cancer Sciences, Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

Alan McIntyreCentre for Cancer Sciences, Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

Giovanni E MannSchool of Cardiovascular and Metabolic Medicine & Sciences, King's British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK. Electronic address: giovanni.mann@kcl.ac.uk.

Joern R SteinertSchool of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, NG7 2UH, UK. Electronic address: joern.steinert@nottingham.ac.uk.

Funding

British Heart Foundation PG/24/11598Wellcome Trust 218466/Z/19Z

6 · The paper itself

Abstract

Human endothelial cells (EC) play a critical role in vascular homeostasis and their function is influenced by oxygen tension. This study investigates for the first time the effects of long-term adaptation (5 days) of two major EC types to physiological oxygen tension (5 kPa) on basal and nitric oxide (NO)-modulated K

Indexed as

Endothelial CellsOxygenPotassium ChannelsApaminHumansHuman Umbilical Vein Endothelial CellsMembrane PotentialsNitric OxidePatch-Clamp TechniquesPyrazolesTetraethylammoniumApaminNitric OxideOxygenPotassium ChannelsPyrazolesTetraethylammoniumTRAM 34Endothelial cellsNitric oxidePhysiological normoxiaPhysiological oxygen tensionPotassium channelsRedox signalling

Identifiers

PMID41496204

DOI10.1016/j.redox.2025.103981

PMCPMC12808508

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.