ArticleMicrobiology spectrum2026
Impact of prolonged infection on SARS-CoV-2 evolution.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Collateral sensitivity-harnessing microbial vulnerabilities as a solution to antimicrobial resistance.Molecular biology reports · 2026Review
- Nuclear receptor-mediated control of bile composition: implications for gallstone formation.Irish journal of medical science · 2026Review
- Microbial architects of cigar fermentation: a critical review of beneficial roles in quality enhancement and detrimental potential for mould spoilage.Archives of microbiology · 2026Review
- Blood-Brain Barrier Changes and Related Microvascular Outcomes in Long-COVID: A Comprehensive Review.Life (Basel, Switzerland) · 2026Review
- Intergeneric conjugative transfer of plasmid-associated antibiotic resistance genes from environmental Aeromonas spp. to gram-negative recipient strains.Molecular biology reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunocompromised patients with prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may serve as reservoirs for viral evolution, with suboptimal immune responses facilitating the accumulation of adaptive mutations. This study aimed to characterize the drivers of SARS-CoV-2 adaptive evolution in such hosts through genomic surveillance. We retrospectively analyzed 24 patients with long-term positive nasopharyngeal reverse transcription-polymerase chain reaction results (symptom onset duration: 7-14 days on average, 1 HIV-positive patient with >20 days of infection). Most infections (April-May 2022) were caused by Omicron variants (predominantly BA.2). Phylogenetic analysis revealed accelerated viral evolution in patients with diverse underlying diseases (e.g., HIV and esophageal cancer). A total of 78 intrahost single-nucleotide variants were identified, with ORF1ab (53.8%) and the Spike protein coding region (20.5%) being hotspots. Notably, the HIV-positive patient's virus developed unique mutations: NSP3-T779I, NSP15-A94T, and Spike double mutations N440K and I794T. Functional assays showed that the N440K/I794T double mutation significantly enhanced infectivity in Hela-hACE2 cells (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.