Evidence map›Paper›PMID 41495987›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Renalase stimulates aldosterone production via PMCA4b/cAMP in NCI-H295R cells.

Ru Fu, Miao Huang, Tao Liu, Ye Chen, Xiaogang Li, Weihong Jiang

Abstract read
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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ru FuDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Miao HuangDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Tao LiuDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Ye ChenDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Xiaogang LiDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Weihong JiangDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently observed a significantly higher level of renalase (RNLS) in aldosterone-producing adenomas (APAs) than in the APA-adjacent adrenal glands (AAGs). RNLS is a flavin adenine dinucleotide-dependent monoamine oxidase. In this study, we investi-gated the effect of RNLS on adrenocortical aldosterone production. RNLS upregulated aldosterone production in adrenocortical cells without interfering with cell proliferation. RNLS (4 μg/ml) increased the mRNA expression of HSD3B2 (

Indexed as

AldosteroneCyclic AMPMonoamine OxidaseCell ProliferationDose-Response Relationship, DrugHumansStructure-Activity RelationshipAldosteroneCyclic AMPMonoamine OxidaserenalasealdosteronecAMP signalingPMCA4bRenalasetranscription factors

Identifiers

PMID41495987
PMCPMC12781950

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.