Evidence map›Paper›PMID 41495964›Full record

ReviewFEBS letters2026

IPMK at the crossroads of cellular signaling in health and disease.

Sera Kim, Jaeseung Ryu, Jae Yeong Park, Ji Kwang Kim, Lauren S Whang, Seyun Kim

Abstract readReview
In one paragraph

Review in FEBS letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sera KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Jaeseung RyuDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Jae Yeong ParkDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Ji Kwang KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Lauren S WhangKrieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Seyun KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.ORCID https://orcid.org/0000-0003-0110-9414

Funding

National Research Foundation of Korea RS-2024-00415888National Research Foundation of Korea RS-2025-00519836The KAIST Quantum + X Convergence R&D Project
6 · The paper itself

Abstract

Inositol phosphates (InsPs) represent a conserved class of water-soluble signaling molecules found in all eukaryotes. Their biosynthesis involves a tightly regulated enzymatic network, with inositol polyphosphate multikinase (IPMK) functioning as a pivotal catalytic hub. IPMK exhibits broad substrate specificity, phosphorylating various InsPs and phosphatidylinositol 4,5-bisphosphate. Beyond its enzymatic activity, IPMK also modulates key signaling pathways through noncatalytic mechanisms, including direct interactions with protein partners. This review highlights the functional attributes of IPMK, its diverse roles in cellular physiology and disease, and outlines current challenges and future directions in IPMK research.

Indexed as

Phosphotransferases (Alcohol Group Acceptor)Signal TransductionAnimalsHumansInositol PhosphatesPhosphorylationSubstrate SpecificityInositol Phosphatesinositol polyphosphate multikinasePhosphotransferases (Alcohol Group Acceptor)differentiationdiseasehomeostasisimmunityinfectioninositol phosphateIPMKmetabolismsignalingtranscription

Identifiers

PMID41495964
PMCPMC13573085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.