ArticleInternational journal of retina and vitreous2026
Segmental choroidal vascularity in Acute Vogt-Koyanagi-Harada disease.
Article in International journal of retina and vitreous, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo analyse the changes in choroidal structures, both in the inner and outer choroid, including choroidal vascularity index (CVI) and choroidal stromal index (CSI) in patients with Vogt-Koyanagi-Harada (VKH) disease during the acute phase and after disease resolution using optical coherence tomography (OCT).
methodsThis was a retrospective, observational study of eyes with acute VKH disease. An automated image binarization protocol was used to analyse the choroid. Choroidal thickness, area, and choroidal vascular and stromal area were calculated using the same protocol. Qualitative changes in the morphology of choroidal vessels were also analysed. Changes in choroidal parameters and correlations before and after treatment were analysed.
resultsWe included 55 eyes (29 patients) of acute VKH (9 males and 20 females). Significant reductions were observed in inner, outer, and total choroidal thickness, and in both stromal and vascular areas of the choroid after treatment (p < 0.01). However, no significant changes were noted in CVI or CSI. Additionally, 91% of eyes exhibited a horizontally oval or “slit-like” configuration of choroidal vessels following disease resolution, which was associated with a thinner choroid. On regression analysis, worse visual acuity at baseline and higher inner choroidal thickness were associated with greater improvement in visual acuity, and thinner total choroidal thickness at baseline was associated with thinner choroidal thickness at the final visit.
conclusionChoroidal structural parameters in both the inner and outer choroid significantly decrease after VKH disease resolution. However, both CVI and CSI remained unchanged. Also, horizontally oval or “slit-like” choroidal vessels may be a novel OCT biomarker of resolved VKH disease. CLINICAL TRIAL REGISTRATION NUMBER: N/A
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