Evidence map›Paper›PMID 41495820›Full record

Observational studyRespiratory research2026

Detection of nocturnal desaturation and hypercapnia using accelerometer-integrated pulse oximetry: a prospective observational study.

Takamasa Kitajima, Hideki Tajima, Eri Nohara, Shiori Jinno, Chie Morimoto, Daiki Inoue, Satoshi Marumo, Atsushi Miwa, Motonari Fukui

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takamasa KitajimaRespiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan. m-kitajima@kitano-hp.or.jp.
Hideki TajimaVital Sensing Department, Modality Business Unit, Healthcare Business Headquarters, KONICA MINOLTA, INC, Tokyo, Japan.
Eri NoharaRespiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
Shiori JinnoRespiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
Chie MorimotoRespiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
Daiki InoueRespiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
Satoshi MarumoRespiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
Atsushi MiwaVital Sensing Department, Modality Business Unit, Healthcare Business Headquarters, KONICA MINOLTA, INC, Tokyo, Japan.
Motonari FukuiRespiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSleep-related hypoventilation, particularly during rapid eye movement (REM) sleep, has been linked to pulmonary hypertension and recurrent exacerbations in individuals with advanced chronic respiratory or neuromuscular diseases. Overnight pulse oximetry (OPO) serves as a valuable screening tool to depict episodic oxygen desaturation resulting from sleep-related hypoventilation. However, differentiating nocturnal desaturation caused by physical activity from that attributable to sleep-related hypoventilation remains clinically challenging. This study aimed to determine whether the integration of accelerometer data with OPO readings can assist in distinguishing exertional nocturnal desaturation from desaturation due to sleep-related hypoventilation.

methodsBetween July 2021 and December 2022, a prospective enrollment was conducted among consecutive individuals with stable chronic respiratory disorders who reported worsening exertional dyspnea. Participants underwent overnight monitoring involving transcutaneous carbon dioxide pressure (PtcCO₂) and pulse oximetry integrated with accelerometer sensors. The number of exertion-associated desaturation events was compared between participant self-reports and acceleration-derived data. Additionally, the diagnostic accuracy of accelerometer-integrated pulse oximetry for detecting episodic nocturnal hypercapnia was assessed using PtcCO₂ monitoring as the reference standard. The primary endpoint was the patient-level diagnostic accuracy of accelerometer-integrated pulse oximetry in detecting episodic nocturnal hypercapnia.

resultsThirty-six individuals were enrolled, with a median age of 78.0 (IQR: 72.0-82.0) years and a mean daytime arterial carbon dioxide pressure (PaCO₂) of 42.4 ± 6.9 mmHg. Of the 89 desaturation events observed, 56 (62.9%) were identified as exertion-related using accelerometer data, including 19 events (21.3%) that were not self-reported. The device demonstrated a sensitivity of 100% (95% CI: 79.6-100%) and a specificity of 75.7% (95% CI: 64.8-84.0%) in identifying episodic nocturnal hypoxia associated with hypercapnia. At the patient level, sensitivity and specificity were 100% (95% CI: 100-100%) and 73.1% (95% CI: 53.9-86.3%), respectively. At the event level, sensitivity and specificity were 100% (95% CI: 79.6-100%) and 75.7% (95% CI: 64.8-84.2%), respectively.

conclusionAmong individuals with suspected sleep-related breathing disorders, accelerometer-integrated pulse oximetry may serve as a valuable tool to distinguish nocturnal desaturation episodes caused by exertion from those due to sleep-related hypoventilation. These findings suggest that accelerometer-integrated pulse oximetry could offer a feasible screening method for detecting sleep-related hypoventilation in outpatient settings lacking access to PtcCO

Indexed as

AccelerometryHypercapniaOximetryOxygen SaturationAgedFemaleHumansMaleMiddle AgedProspective StudiesCOPDDiagnostic accuracyEpisodic nocturnal hypercapniaNocturnal exertional desaturationPulse oximetrySleep-related hypoventilationTranscutaneous carbon dioxide monitoring

Identifiers

PMID41495820
PMCPMC12870876

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.