Evidence map›Paper›PMID 41495763›Full record

ArticleCritical care (London, England)2026

A prospective clinical evaluation of new ECCO2R technology in mild to moderate ARDS patients: assessing ultra-lung-protective ventilation with PRISMALUNG.

Alain Combes, Bruno Levy, Romain Tapponnier, Gilles Capellier, Armand Mekontso Dessap, Thibault Duburcq, Vincent Castelain, Jean-Marie Forel, Fabrice Uhel, Julien Mayaux and 6 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04617093 (A Post-Market Study of Performance and Safety of Low-flow Extracorporeal Carbon Dioxide Removal Using PrismaLung+ in Patients With Mild to Moderate Acute Respiratory Distress Syndrome), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04617093 nacompletednot on this map

A Post-Market Study of Performance and Safety of Low-flow Extracorporeal Carbon Dioxide Removal Using PrismaLung+ in Patients With Mild to Moderate Acute Respiratory Distress Syndrome

TypeinterventionalSponsorVantive Health LLCRan2021 to 2024Enrolled63ConditionsMild to Moderate Acute Respiratory Distress SyndromeArmsPrismaLung+
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The evolution of ECCO₂R: rethinking pump selection.Critical care (London, England) · 2026
    Article
  5. Article
  6. Minimally invasive extracorporeal COCritical care (London, England) · 2026
    Observational
  7. Extracorporeal COAnnals of intensive care · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alain CombesSorbonne Université, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Sorbonne Université Hôpital Pitié-Salpêtrière,47, boulevard de l'Hôpital, Paris, F-75013, France. alain.combes@aphp.fr.ORCID http://orcid.org/0000-0002-6030-3957
Bruno LevyBrabois Adults Hospital, Medical Intensive Care Unit, CHRU, Vandoeuvre-lès-Nancy, France.
Romain TapponnierHospital Jean Minjoz, Medical Intensive Care Unit, CHU, Besançon, France.
Gilles CapellierHospital Jean Minjoz, Medical Intensive Care Unit, CHU, Besançon, France.
Armand Mekontso DessapHenri-Mondor University Hospital, Intensive Care Unit, APHP, Créteil, France.
Thibault DuburcqRoger Salengro Hospital, Intensive Care Unit, CHRU, Lille, France.
Vincent CastelainHautepierre Hospital, Medical Intensive Care, CHRU, Strasbourg, France.
Jean-Marie ForelMarseille University Hospital Center - North Hospital, Medical Intensive Care Unit, Acute Respiratory Distress and Severe Infections, Marseille, France.
Fabrice UhelLouis Mourier Hospital, Intensive Care Unit, APHP, Colombes, France.
Julien MayauxLa Pitié- Salpêtrière University Hospital, Pulmonology Intensive Care Unit, APHP, Paris, France.
Jacques GoldsteinCardio Gold Consulting, Baxter/Vantive Consultant, Lessines, Belgium.
Jörg KurzVantive Healthcare LLC, Worldwide Medical, Unterschleissheim, Germany.
Kai HarenskiVantive Healthcare LLC, Worldwide Medical, Unterschleissheim, Germany.
William MontgomeryVantive US Healthcare LLC, Worldwide Medical, Illinois, USA.
Rhea ParrenoVantive US Healthcare LLC, Worldwide Medical, Illinois, USA.
Samir JaberSaint Eloi Hospital, Intensive Care Unit, CHU, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtracorporeal carbon dioxide removal (ECCO

methodsBetween April 2021 and December 2023, 58 patients were treated with ECCO

resultsDuring V

conclusionThis study demonstrates that hypercapnic acidosis occurring during ultra-low V

trial registrationClinicaltrials.gov: NCT04617093, Registration date: 30 October 2020.

Indexed as

Carbon DioxideExtracorporeal Membrane OxygenationRespiration, ArtificialRespiratory Distress SyndromeAdultAgedFemaleFranceHumansHypercapniaMaleMiddle AgedProspective StudiesTidal VolumeCarbon DioxideAcute respiratory distress syndromeExtracorporeal carbon dioxide removalMechanical ventilationProtective ventilation.

Identifiers

PMID41495763
PMCPMC12784554

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.