ArticleBMC neurology2026
Association of early acetaminophen administration with mortality among critically ill patients with ischemic stroke: a retrospective cohort study.
Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe therapeutic effect of early acetaminophen administration in patients diagnosed with ischemic stroke remains inconclusive. In particular, its impact on clinical outcomes among critically ill patients admitted to the intensive care unit (ICU) has not been fully characterized. This study aimed to evaluate the association between early acetaminophen exposure and clinical outcomes in patients in the ICU with ischemic stroke through a retrospective analysis of the Medical Information Mart for Intensive Care IV (MIMIC-IV) version 2.2 database.
methodsA total of 1,419 ICU patients with a diagnosis of ischemic stroke were included in this retrospective database study. To address baseline differences between treatment groups, propensity score matching (PSM) was performed. The primary outcome was 90-day all-cause mortality. Secondary outcomes included 30-day mortality, ICU length of stay, and in-hospital mortality. Analyses were conducted in the matched cohort to assess the associations between early acetaminophen administration, defined as administration within 48 h of ICU admission, and these outcomes.
resultsOf the study population, 839 patients received acetaminophen within 48 h of ICU admission, and 580 did not. Following PSM, 505 matched pairs were obtained. Kaplan–Meier survival analysis demonstrated significantly improved survival in the early acetaminophen group compared to the untreated group (p < 0.05). Multivariable Cox proportional hazards regression analysis, adjusted for relevant covariates, demonstrated that early acetaminophen exposure was associated with a lower 90-day mortality rate (27.72% vs. 37.03%; hazard ratio [HR] = 0.73; 95% confidence interval [CI] = 0.59 to 0.91; p < 0.05).
conclusionEarly acetaminophen administration within 48 h of ICU admission was associated with lower mortality among patients with ischemic stroke. Additional improvements were observed in 30-day mortality, in-hospital mortality, and ICU length of stay.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.