Evidence map›Paper›PMID 41495680›Full record

ArticleBMC cardiovascular disorders2026

Noninvasive screening for surgery in adults with simple shunting congenital heart disease.

Xingxing Sun, Yang Chen, Jianhua Xu, Hongyu Gao, Hanqing Zhu, Bigyan Pudasaini, Wenlan Yang, Yuan Cao, Jian Guo

Abstract read
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In one paragraph

Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xingxing Sun *Department of pulmonary Function Test, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, 200433, China.
Yang Chen *Department of Pneumoconiosis, Pulmonary Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai, 200433, China.
Jianhua Xu *Department of pulmonary Function Test, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, 200433, China.
Hongyu GaoDepartment of pulmonary Function Test, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, 200433, China.
Hanqing ZhuDepartment of pulmonary Function Test, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, 200433, China.
Bigyan PudasainiDepartment of Internal Medicine, Jiahui international hospital, Shanghai, 200040, China.
Wenlan YangDepartment of pulmonary Function Test, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, 200433, China.
Yuan CaoDepartment of pulmonary Function Test, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, 200433, China.
Jian GuoDepartment of pulmonary Function Test, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, 200433, China. jianjian11121978@163.com.

Funding

the Clinical research project of Shanghai Pulmonary Hospital FKLY20020the Science and Technology Commission of Shanghai Municipality Project 22xtcx00104the Scientific research project of Shanghai Municipal Health Commission 202040321
6 · The paper itself

Abstract

objectivesThe aim of this study was to use non-invasive parameters to assess eligibility to undergo surgery in patients with adult congenital heart disease (CHD).

methodsThis is a single-center retrospective study that collected patients’ demographic data, right heart catheterization, complete blood count, N-terminal pro-brain natriuretic peptide (NT-proBNP), arterial blood gas, pulmonary function test (PFT), cardiopulmonary exercise testing (CPET), and echocardiographic parameters. Surgical eligibility of patients was evaluated based on hemodynamic parameters, specifically pulmonary vascular resistance (PVR) < 4.6 WU and pulmonary vascular resistance index (PVRI) < 8 WU ▪ m2. Univariate analysis was employed to compare baseline parameters between the two patient groups. Independent predictive factors were determined using binary logistic regression analysis.

resultsA total of 81 patients with adult CHD were included in the study, with 34 qualifying for surgery and 47 not meeting the criteria for surgery. The group eligible for surgery exhibited superior hemodynamics, higher oxygen partial pressure, and better diffusion capacity compared to the non-eligible group. Echocardiographic findings revealed lower systolic pulmonary artery pressure (SPAP) in the eligible group (79.23 ± 23.56 vs. 98.91 ± 20.23 mmHg, p = 0.00), higher tricuspid annular plane systolic excursion (TAPSE) (2.10 (1.88, 2.50) vs. 1.81 (1.70, 2.01) cm, p = 0.001), and increased TAPSE/SPAP ratio (0.32 ± 0.14 vs. 0.20 ± 0.59 mm/mmHg, p = 0.00). TAPSE/SPAP emerged as an independent predictor, with an area under the receiver operating characteristic (ROC) curve of 0.81 (95% CI: 0.70–0.92, p < 0.01).

conclusionsThe echocardiographic parameter TAPSE/SPAP may be a valuable index to evaluate whether patients with coronary artery disease are suitable for surgery.

Indexed as

Cardiac CatheterizationCardiac Surgical ProceduresHeart Defects, CongenitalHemodynamicsPatient SelectionPulmonary ArteryAdultBiomarkersClinical Decision-MakingExercise TestFemaleHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Congenital heart diseaseEchocardiogramSurgical eligibility

Identifiers

PMID41495680
PMCPMC12874752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.