Evidence map›Paper›PMID 41495649›Full record

ArticleBMC genomics2026

Symbiont-mediated detoxification: Wolbachia alters the transcriptomic and metabolic landscape of Drosophila under nicotine stress.

Yang Fang, Maojiu Ran, Lingzhi Chen, Qijun Xie, Xuan Li, Ya Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yang Fang *Hunan Key Laboratory of Biomedical Nanomaterials and Devices, School of Biological Science and Medical Engineering, Hunan University of Technology, Zhuzhou, 412007, China.
Maojiu Ran *School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, 430079, P. R. China.
Lingzhi Chen *Hunan Key Laboratory of Biomedical Nanomaterials and Devices, School of Biological Science and Medical Engineering, Hunan University of Technology, Zhuzhou, 412007, China.
Qijun XieHunan Key Laboratory of Biomedical Nanomaterials and Devices, School of Biological Science and Medical Engineering, Hunan University of Technology, Zhuzhou, 412007, China.
Xuan LiHunan Key Laboratory of Biomedical Nanomaterials and Devices, School of Biological Science and Medical Engineering, Hunan University of Technology, Zhuzhou, 412007, China.
Ya ZhengSchool of Life Sciences, Shanghai Normal University, Shanghai, 200234, China. zhengyahb@shnu.edu.cn.

Funding

National Natural Science Foundation of China 31970471
6 · The paper itself

Abstract

Nicotine (NE), a principal alkaloid in tobacco, functions as both a neurotoxin and a candidate for therapeutic applications. This research explores the tripartite interactions among the host organism, its endosymbiotic microbiota, and the toxicant agent, utilizing Drosophila melanogaster and its native symbiont Wolbachia (wMel Pop strain). To elucidate the mechanisms governing host-microbe-toxicant dynamics, the influence of nicotine on the developmental biology of Drosophila was assessed through dietary administration to two strains: wMel Pop-infected and uninfected Drosophila (Dmel T). Additionally, the impact of nicotine on Drosophila ontogeny and the regulatory role of Wolbachia were examined employing integrated dual transcriptomic and metabolomic analyses. This multi-omics approach demonstrated that Wolbachia infection modulates the host’s transcriptional and metabolic profiles, consequently influencing its response to nicotine exposure. The findings emphasize the critical influence of host-associated microbiota in modulating toxicokinetic pathways in Drosophila.

Indexed as

Drosophila melanogasterMetabolomeNicotineStress, PhysiologicalSymbiosisTranscriptomeWolbachiaAnimalsFemaleGene Expression ProfilingInactivation, MetabolicMetabolomicsMultiomicsNicotineDrosophilaMetabolomicsNicotineTranscriptomicsWolbachia

Identifiers

PMID41495649
PMCPMC12870886

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.