Evidence map›Paper›PMID 41495587›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2026

High prevalence of fosfomycin resistance among ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates in a tertiary hospital from Jiangxi Province, South China.

Min Li, Ping Li, Jian Cui, Peng Zhu, Hui Guo, Wei Zuo, Wenjian Liao

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Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Min LiDepartment of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang, Jiangxi, 330006, PR China.
Ping LiDepartment of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang, Jiangxi, 330006, PR China.
Jian CuiDepartment of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang, Jiangxi, 330006, PR China.
Peng ZhuDepartment of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang, Jiangxi, 330006, PR China.
Hui GuoDepartment of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang, Jiangxi, 330006, PR China.
Wei ZuoDepartment of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang, Jiangxi, 330006, PR China. 11545394@qq.com.
Wenjian LiaoDepartment of Respiratory and Critical Care, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang, Jiangxi, 330006, PR China. 897854867@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aimed to characterize the prevalence of fosfomycin resistance in clinical carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) isolates.

methodsCommon drug resistance genes and virulence genes were amplified by polymerase chain reaction (PCR) and verified by whole-genome sequencing. The potential virulence of all the clinical CRKP strains was tested in a Galleria mellonella infection model.

resultsA total of 171 CR-hvKP isolates collected from a Chinese tertiary hospital were analyzed for fosfomycin resistance. 71 strains (41.5%) were sensitive to fosfomycin, and 100 strains (58.5%) were resistant to fosfomycin. All the clinical isolates were found to carry fosfomycin genes fosA and fosA6. Only one fosfomycin-resistant isolate was found to carry the gene fosA3. In addition to the modification of target enzyme murA, the mechanisms of fosfomycin resistance also involve the dysfunction of the transport system including glpt, uhpT, and their regulatory gene CyaA mutation deletion. The Galleria mellonella infection assays confirmed that all the CRKP strains exhibited hypervirulence.

conclusionCumulatively, fosfomycin resistance in CR-hvKP is mediated by diverse mechanisms and is highly prevalent in a tertiary hospital from Jiangxi Province, South China. It is therefore critical to continuously monitor the epidemiology of these fosfomycin-resistant CR-hvKP while simultaneously minimizing potential risks from fosfomycin-resistant CR-hvKP.

Indexed as

Anti-Bacterial AgentsCarbapenem-Resistant EnterobacteriaceaeCarbapenemsDrug Resistance, BacterialFosfomycinKlebsiella InfectionsKlebsiella pneumoniaeAnimalsBacterial ProteinsChinaHumansMicrobial Sensitivity TestsMothsPrevalenceTertiary Care CentersVirulenceAnti-Bacterial AgentsBacterial ProteinsCarbapenemsFosfomycinCarbapenem-resistantFosfomycin resistanceHypervirulenceK. pneumoniaeST11

Identifiers

PMID41495587
PMCPMC12904918

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