Evidence map›Paper›PMID 41495578›Full record

ArticleIndian journal of pediatrics2026

Sepsis Associated Necrotizing Enterocolitis (SA-NEC) in Preterm Infants: Risk Factors and Clinical Outcomes.

Chinnathambi Nandakumar, Chaitra Angadi, Balaji Ramachandrin, Bethou Adhisivam, Usha Devi

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Article in Indian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chinnathambi NandakumarDepartment of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605 006, India.ORCID 0009-0008-3168-5547
Chaitra AngadiDepartment of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605 006, India.
Balaji RamachandrinDepartment of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605 006, India.
Bethou AdhisivamDepartment of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605 006, India.
Usha DeviDepartment of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605 006, India. dr.ushaa@gmail.com.ORCID 0000-0002-9487-4651

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is a major gastrointestinal emergency in preterm infants, often associated with sepsis that worsens the outcomes. Data from low- and middle-income settings are limited. This retrospective study described the clinical spectrum and short-term outcomes of NEC and compared sepsis-associated NEC (SA-NEC) with non-sepsis-associated NEC (non-SA NEC). Preterm infants with ≥ stage 2 NEC admitted between March 2022 and February 2025 were included. SA-NEC was defined as NEC with culture-proven sepsis at onset of illness. Of 55 infants with NEC (median gestational age 31 wk 1 d; birth weight 1,195 g), 54.5% had SA-NEC. Compared with non-SA NEC, SA-NEC had higher rates of acute kidney injury [OR 9.75; 95% CI 2.6-36.6, p < 0.001], perforation [OR 4.6; 1.3-16.6, p = 0.02] and mortality [OR 8.9; 2.52-31.4, p < 0.001]. SA-NEC represents a more severe clinical phenotype with significantly poorer outcomes. Strengthening infection control practices and adopting comprehensive NEC prevention strategies are crucial to improving outcomes in preterm infants.

Indexed as

Enterocolitis, NecrotizingInfant, Premature, DiseasesSepsisAcute Kidney InjuryFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMaleRetrospective StudiesRisk FactorsInfantInfant mortalityIntestinal perforationNecrotizing enterocolitisPrematureSepsis

Identifiers

PMID41495578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.