Evidence map›Paper›PMID 41495560›Full record

ArticleSurgery today2026

Combined prophylactic negative-pressure wound therapy and preoperative oral antibiotics reduce perineal wound complications after abdominoperineal resection.

Michihiro Kudou, Yoshiki Morino, Tomoya Matsuda, Koji Tarumto, Yuzo Yamazato, Shoichiro Hikami, Ryoichi Tanaka, Kenichiro Fukuda, Yoshiki Yamamoto, Yoshihiro Shimizu and 1 more

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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11 authors.

Michihiro KudouDepartment of Digestive Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan. posit@koto.kpu-m.ac.jp.
Yoshiki MorinoDepartment of Digestive Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan.
Tomoya MatsudaDepartment of Emergency Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan.
Koji TarumtoDepartment of Emergency Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan.
Yuzo YamazatoDepartment of Digestive Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan.
Shoichiro HikamiDepartment of Digestive Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan.
Ryoichi TanakaDepartment of Emergency Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan.
Kenichiro FukudaDepartment of Digestive Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan.
Yoshiki YamamotoDepartment of Digestive Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan.
Yoshihiro ShimizuDepartment of Digestive Surgery, Kyoto Okamoto Memorial Hospital, Kyoto, Japan.
Atsushi ShiozakiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePerineal wound complications after abdominoperineal resection (APR) remain a major concern, often leading to poor patient outcomes. Prophylactic negative-pressure wound therapy (pNPWT) and oral antibiotics (OA) administration have individually shown promise in reducing surgical site infections (SSIs). The present study investigated their combined effect for the prevention of perineal wound complications after APR.

methodsThis retrospective study included patients who underwent APR for lower rectal cancer between April 2016 and March 2025. Patients were divided into two groups: conventional treatment (CT) and those receiving a combination of pNPWT and preoperative OA (pNPWT + OA). Postoperative complications were compared.

resultsSixteen patients were included in the pNPWT + OA group and 14 in the CT group. The incidence of superficial perineal SSIs was significantly lower in the pNPWT + OA group than in the CT group (6.3% vs. 42.9%, p = 0.030), with no cases of wound dehiscence (0% vs. 28.6%, p = 0.036). Furthermore, preoperative albumin < 3.0 g/dL correlated with the incidence of perineal SSIs and wound dehiscence.

conclusionThe combined use of pNPWT and OA was associated with a reduction in perineal wound infections and dehiscence following APR. This approach may improve postoperative outcomes; however, these findings are hypothesis-generating and should be validated in large-scale, prospective studies, including cost-effectiveness analyses.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisNegative-Pressure Wound TherapyPerineumPostoperative ComplicationsPreoperative CareProctectomyRectal NeoplasmsSurgical Wound DehiscenceSurgical Wound InfectionAdministration, OralAgedCombined Modality TherapyFemaleHumansIncidenceAnti-Bacterial AgentsAbdominoperineal resectionAntibioticsNegative pressure wound therapyRectal cancerSurgical site infection

Identifiers

PMID41495560

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