Evidence map›Paper›PMID 41495520›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

The effectiveness and safety of combining platelet-rich plasma with cartilage tympanoplasty type 1 to treat tympanic membrane perforations: a systematic review and meta-analysis.

Yun Jin Kang, Gulnaz Stybayeva, Se Hwan Hwang

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Yun Jin KangDepartment of Otolaryngology-Head and Neck Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Gulnaz StybayevaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Se Hwan HwangDepartment of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. yellobird@catholic.ac.kr.ORCID http://orcid.org/0000-0002-2838-7820

Funding

National Research Foundation of Korea 2022R1F1A1066232
6 · The paper itself

Abstract

purposeWe evaluated the effectiveness of cartilage tympanoplasty type 1 combined with platelet-rich plasma (PRP) compared to cartilage tympanoplasty type 1 alone in dry tympanic membrane (TM) perforation due to chronic otitis media, demonstrating the safety and efficacy of PRP in tissue repair and regeneration.

methodsData were retrieved from the literature up to April 2025. Outcomes of interest were success rate (complete closure of the TM postoperatively), postoperative air-conduction (AC) threshold, and changes in air-bone gap (ABG) and AC threshold (preoperatively to postoperatively). Pooled effects were calculated using standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals (CIs).

resultsPRP-augmented cartilage tympanoplasty type 1 significantly improved ABG and AC compared to cartilage tympanoplasty type 1 alone (SMD 0.4517; 95% CI [0.1010; 0.8025], I

conclusionThe autologous PRP application during cartilage tympanoplasty type 1 leads to higher success rates and greater hearing improvement, and also increases the success rate during all follow-up periods.

Indexed as

CartilagePlatelet-Rich PlasmaTympanic Membrane PerforationTympanoplastyCombined Modality TherapyHumansOtitis MediaTreatment OutcomeCartilageMeta-analysisPlatelet rich plasmaRepairTympanic membraneTympanoplasty

Identifiers

PMID41495520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.