Evidence map›Paper›PMID 41495513›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Preoperative inflammatory ratios as predictors of occult nodal disease in supraglottic carcinoma: implications for transoral laser microsurgery planning.

Luis Juesas-Iglesias, Mario Sánchez-Canteli, Daniel Pedregal Mallo, Juana M García-Pedrero, Fernando López, Juan P Rodrigo

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Luis Juesas-IglesiasDepartment of Otolaryngology, Hospital Universitario Germans Trias I Pujol, Badalona, Spain.
Mario Sánchez-CanteliDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Av Roma , Oviedo, SN, 33011, Spain.
Daniel Pedregal MalloDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Av Roma , Oviedo, SN, 33011, Spain.
Juana M García-PedreroDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Av Roma , Oviedo, SN, 33011, Spain.
Fernando LópezDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Av Roma , Oviedo, SN, 33011, Spain. flopeza1981@gmail.com.ORCID http://orcid.org/0000-0001-7019-9746
Juan P RodrigoDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Av Roma , Oviedo, SN, 33011, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLymph node metastasis is widely recognized as the most significant prognostic factor in head and neck squamous cell carcinomas (HNSCC). While preoperative imaging techniques have improved, occult metastases often remain undetected, thereby complicating treatment decisions in clinically node-negative (cN0) patients.

methodsThis retrospective study investigates the predictive value of systemic inflammatory markers—neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SIII)—in assessing the risk of occult lymph node metastasis in 76 patients with supraglottic squamous cell carcinoma treated with transoral laser microsurgery and neck dissection. Pre-treatment hematological parameters were analyzed, and receiver operating characteristic (ROC) curves identified optimal cut-off values for each marker.

resultsAmong the 76 cN0 patients, 37 (48.6%) had occult nodal metastases (pN+). NLR exhibited the highest predictive value (Area Under the Curve [AUC] = 0.634), showing a significant association between elevated NLR (> 2.64) and nodal metastases (66.6% vs. 37.0%, p = 0.01). Multivariable logistic regression confirmed NLR as the strongest independent predictor (Odds Ratio [OR] = 5.36; p = 0.004). Elevated SIII and PLR also showed significant associations with nodal metastases and tumor stage, though these were less pronounced. Furthermore, high SIII was linked to reduced overall survival (p = 0.004).

conclusionsAlthough a high NLR indicates an increased metastatic risk, its limited negative predictive value (63%) suggests it is insufficient on its own to guide the decision to forego elective neck dissection (END). Therefore, it cannot independently determine whether an END should be performed. Inflammation-based blood indices, particularly NLR, are accessible and cost-effective tools, but further studies are needed to clarify their role in risk stratification and in personalizing treatment planning for patients with supraglottic carcinoma.

Indexed as

Blood markersInflammatory markersNeck dissectionNodal metastasisSupraglottic cancerSystemic inflammation

Identifiers

PMID41495513

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