Evidence map›Paper›PMID 41495506›Full record

Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Survival rates in head and neck cutaneous squamous cell carcinoma with nodal metastases: a multicenter study.

Matteo Fermi, Pierre Guarino, Francesco Chiari, Edoardo Serafini, Daria Maria Filippini, Giuseppe Ferrulli, Margherita Basso, Francesco Mattioli, Claudio Donadio Caporale, Daniele Marchioni and 2 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matteo Fermi *Department of Otolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero- Universitaria Di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-2727-0321
Pierre Guarino *Otolaryngology Head and Neck Unit - "Santo Spirito" Hospital, Pescara, Italy.ORCID http://orcid.org/0000-0003-3796-9483
Francesco ChiariOtolaryngology Head and Neck Unit - "Santo Spirito" Hospital, Pescara, Italy. francesco.chiari.med@gmail.com.ORCID http://orcid.org/0000-0001-5600-3938
Edoardo SerafiniDepartment of Otolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero- Universitaria Di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-4519-1299
Daria Maria FilippiniAlma Mater Studiorum-Università di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0003-3328-7282
Giuseppe FerrulliOtolaryngology Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.ORCID http://orcid.org/0009-0007-8080-4066
Margherita BassoOtolaryngology Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.ORCID http://orcid.org/0000-0002-0457-6299
Francesco MattioliOtolaryngology Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.ORCID http://orcid.org/0000-0002-1481-668X
Claudio Donadio CaporaleOtolaryngology Head and Neck Unit - "Santo Spirito" Hospital, Pescara, Italy.
Daniele MarchioniOtolaryngology Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.ORCID http://orcid.org/0000-0002-8004-7284
Livio PresuttiDepartment of Otolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero- Universitaria Di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-2752-132X
Gabriele MolteniDepartment of Otolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero- Universitaria Di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0001-7764-2122

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe primary objective of this study was to identify potential prognostic factors influencing disease control and survival outcomes in patients with neck metastases (NLM) and/or intraparotid metastases (PLM) arising from cutaneous squamous cell carcinoma (cSCC) of the head and neck. A secondary aim was to compare patients with isolated NLM, isolated PLM, and concurrent NLM/PLM. STUDY DESIGN AND

methodsAn observational, retrospective multicenter study included 68 patients with nodal metastatic cSCC treated at the Head and Neck Units of Bologna, Modena, and Pescara (2014-2024). Clinical, pathological, and treatment variables were analyzed for associations with survival using univariate and multivariate Cox regression models (IBM SPSS).

resultsThe cohort included 30 patients with isolated NLM (44%), 14 with isolated PLM (21%), and 24 with both NLM and PLM (35%). At 5 years, DFS was 33.8%, DSS 70.6%, and OS 69.1%. DFS was reduced by extranodal extension (ENE) in PLM (HR 3.95, 95% CI 1.65-9.48, p = .002). DSS was negatively influenced by perineural invasion (HR 4.53, 95% CI 1.02-34.44, p= 0.016), NLM ENE (HR 5.60, 95% CI 1.72-18.19, p = 0.004), and PLM ENE (HR 8.90, 95% CI 2.51-18.90, p < 0.001). OS was independently worsened by PNI (HR 6.16, 95% CI 1.20-31.39, p = 0.029), NLM ENE (HR 5.18, 95% CI 1.67-16.03, p= 0.004), and PLM ENE (HR 7.03, 95% CI 2.24-22.07, p < 0.001). Female sex (36% in isolated PLM vs 3% in isolated NLM, p = .004) and immunosuppression (67% in patients with both NLM and PLM, p = 0.02) were significantly associated with nodal dissemination pattern, but not with survival.

conclusionThis study highlights the prognostic relevance of PNI, ENE, advanced nodal stage, and lack of adjuvant RT in nodal metastatic cSCC. Immunosuppression and female sex appear more related to higher nodal dissemination patterns than to survival.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsSkin NeoplasmsSquamous Cell Carcinoma of Head and NeckAdultAgedAged, 80 and overFemaleHumansLymphatic MetastasisMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateControl of diseaseCutaneous squamous cell cancerNeck metastasesSurvival rate

Identifiers

PMID41495506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.