Evidence map›Paper›PMID 41495501›Full record

ArticleAnnals of surgical oncology2026

Symptom Cluster Trajectories of Cough, Shortness of Breath, and Disturbed Sleep in Patients Undergoing Lung Cancer Surgery: A Longitudinal Study.

Heling Zhou, Junlin Lei, Jia Liao, Yaqin Wang, Wei Dai, Xing Wei, Cheng Lei, Zhuyue Li, Qiuling Shi, Qing Yang

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Heling ZhouSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Junlin LeiSchool of Public Health, Chongqing Medical University, Chongqing, China.
Jia LiaoDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Yaqin WangDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Wei DaiDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Xing WeiDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Cheng LeiDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Zhuyue LiDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Qiuling ShiSchool of Public Health, Chongqing Medical University, Chongqing, China.
Qing YangDepartment of Nursing, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. yangqingsc@163.com.

Funding

Health Commission of Sichuan Province Medical Science and Technology Program 24LCYJZD08
6 · The paper itself

Abstract

backgroundThe symptom cluster of cough, shortness of breath, and disturbed sleep is common in patients undergoing lung cancer surgery, but its longitudinal patterns remain unclear. This study aimed to identify distinct cluster trajectories and associated factors.

methodsData were drawn from a cohort study on perioperative patient-reported outcomes of lung cancer patients. Symptoms were measured with the Perioperative Symptom Assessment for Lung Surgery (PSA-Lung) at eight time points: preoperation, postoperative day 1, at discharge, and 1, 3, 6, 9, and 12 months postdischarge. A parallel-process latent growth curve model identified trajectory classes, and multivariate logistic regression explored associated factors.

resultsAmong 1377 patients, three trajectory classes were identified: persistently low (N = 814, 60.8%), persistently declining (N = 410, 30.7%), and persistently moderate (N = 114, 8.5%). Male sex (OR = 0.59, 95% CI 0.41-0.87, P = 0.01), no readmission (OR = 0.42, 95% CI 0.20-0.89, P = 0.02), were associated with the "persistently low" trajectory. Lower education level of middle school and below (OR = 2.05, 95% CI 1.07-3.92, P = 0.03), annual family income <100,000 CNY (OR = 2.00, 95% CI 1.01-3.97, P = 0.048), lymph node sampling (OR = 0.41, 95% CI 0.17-0.99, P = 0.047), and high hospitalization costs (OR = 1.37, 95% CI 1.14-1.65, P = 0.001) were associated with the "persistently moderate" trajectory.

conclusionsThere is significant heterogeneity in the trajectories of the cough, shortness of breath, and disturbed sleep symptom cluster. Early identification of high-risk groups may facilitate targeted interventions to improve outcomes.

Indexed as

CoughDyspneaLung NeoplasmsPneumonectomyPostoperative ComplicationsSleep Wake DisordersAgedFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedPrognosisCoughDisturbed sleepLung cancerRisk factorsShortness of breathSurgeryTrajectory

Identifiers

PMID41495501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.