Evidence map›Paper›PMID 41495486›Full record

ArticleBiomolecular NMR assignments2026

Backbone resonance assignment of the pentraxin domain of the neuronal pentraxin receptor (NPTXR).

Alexandra K Pozhidaeva, Yunfeng Li, Yulia Pustovalova, Jeffrey C Hoch, David C Martinelli, Bernd Simon, Bing Hao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecular NMR assignments, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandra K PozhidaevaDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington CT, 06030, USA.
Yunfeng LiDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington CT, 06030, USA.
Yulia PustovalovaDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington CT, 06030, USA.
Jeffrey C HochDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington CT, 06030, USA.
David C MartinelliDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT, 06030, USA.
Bernd SimonDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington CT, 06030, USA. bsimon@uchc.edu.
Bing HaoDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington CT, 06030, USA. bhao@uchc.edu.

Funding

Substrate targeting mechanism of a DesCEND pathwayR01GM135592 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAO, BING · 2020 to 2023
$1.9M
Molecular mechanism of the synapse organizer C1QL3R21NS142751 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Bing Hao · 2025 to 2026
$458k
NIGMS NIH HHS R01 GM135592NINDS NIH HHS R21 NS142751
6 · The paper itself

Abstract

Neuronal pentraxin receptor (NPTXR) is a synaptic organizing protein important for excitatory neurotransmission, yet its structural properties remain poorly defined. The conserved C-terminal pentraxin (PTX) domain of NPTXR (NPTXRPTX) is expected to mediate interactions with synaptic partners but has not been structurally characterized. Here, we report near-complete backbone NMR resonance assignments of NPTXRPTX using uniformly 15N, 13C-labeled protein. These assignments provide a foundation for further studies of NPTXR-ligand interactions that drive NPTXR-dependent synapse organization and will advance our understanding of the molecular mechanisms underlying synaptic assembly and maintenance.

Indexed as

C-Reactive ProteinNerve Tissue ProteinsNuclear Magnetic Resonance, BiomolecularAnimalsPentraxinsProtein DomainsC-Reactive ProteinNerve Tissue ProteinsPentraxinsLong pentraxinsNeuronal pentraxinsNPRSolution NMR

Identifiers

PMID41495486
PMCPMC12774934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.