ArticleNPJ digital medicine2026
A machine learning-derived polygenic risk score reveals that healthy lifestyle counteracts obesity-related mortality.
Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of metabolic score for insulin resistance with type 2 diabetes, cancer, and all-cause mortality: a meta-analysis of cohort studies.Frontiers in endocrinology · 2026Pooled it
- Artificial Intelligence-Based Risk Stratification in Obesity Care: From Diagnosis to Personalised Treatment Pathways.Diagnostics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Obesity is influenced by genetic predisposition and lifestyle. The associations among genetic susceptibility to obesity, lifestyle, and all-cause mortality remain unexplored. Our goal is to develop and validate a machine learning model to assess the genetic risk of obesity and examine its association with lifestyle and all-cause mortality. We integrated genetic data from 482,700 UK Biobank participants and 8,607 Nanfang Hospital participants to create and validate a stacked machine learning model, which generates an obesity-related polygenic risk score (OPRS), to evaluate the relationships among genetic risk of obesity, lifestyle, and all-cause mortality. The model achieved area under the receiver operating characteristic curve values of 0.621, 0.616, and 0.565 for the training, internal, and external test cohorts, respectively. A high OPRS is associated with increased all-cause mortality, with a linear relationship observed among individuals with normal weight or overweight. Among individuals with a high genetic risk of obesity, adhering to four healthy lifestyle factors reduced the risk of all-cause mortality by 59% compared to those who did not. Thus, high genetic risk of obesity is associated with higher risk of all-cause mortality, but a healthy lifestyle mitigates this risk.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.