ReviewCEN case reports2026
Renal limited sarcoidosis presenting with non-caseating granulomatous interstitial nephritis in the absence of extrarenal manifestations: a case report and literature review.
Review in CEN case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Probable Renal-Limited Sarcoidosis Presenting With Tubulointerstitial Nephritis Without Granulomas on Renal Biopsy:Sultan Qaboos University medical journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal limited sarcoidosis is an exceptionally rare condition characterized by non-caseating granulomas confined solely to the kidneys, without involvement of other organs. Its diagnosis is challenging because of the absence of systemic manifestations. We present a case of a 74-year-old woman with a history of type 2 diabetes mellitus, papillary thyroid carcinoma, and osteoporosis, who showed progressive renal dysfunction. Laboratory findings revealed elevated serum creatinine and urinary β₂-microglobulin, indicating tubular injury. Kidney biopsy demonstrated granulomatous interstitial nephritis with non-caseating epithelioid cell granulomas. Other potential causes, including infections, drug-induced nephritis, and autoimmune diseases were excluded. Chest computed tomography and gallium-67 scintigraphy revealed no extrarenal involvement. Based on these findings, we diagnosed the patient as having renal limited sarcoidosis. The patient was treated with low dose of oral prednisolone, resulting in significant improvement in renal function and normalization of laboratory parameters. The present case underscores the importance of considering the possibility of renal limited sarcoidosis on differentiating the case with unexplained renal dysfunction, especially when non-caseating granulomas are identified on kidney biopsy and other causes have been excluded. Corticosteroids remain the cornerstone of treatment, with most patients responding favorably. However, in steroid-resistant cases, alternative immunosuppressive agents such as mycophenolate mofetil and infliximab have been employed, though their efficacy and safety require further investigation. In this article, we present this rare case in addition to providing comprehensive literature review of previously cases to summarize clinicopathological characters, treatment strategies, and renal outcomes of renal-limited sarcoidosis for future clinical management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.