ArticleScientific reports2026
Ameliorative effects of tallow and olive oil on hyperlipidemia-induced atherogenesis in male albino rats.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperlipidemia and atherosclerosis are the major contributors to cardiovascular morbidity and mortality worldwide. This study aimed to evaluate the ameliorative effects of sheep tallow (SHT), bovine tallow (BT), and olive oil (OL) on lipid profiles, oxidative stress, inflammation, and atherosclerotic lesions in a rat model of atherogenesis induced by a high-fat diet. Rat groups received an atherogenic diet (AGD) containing cholesterol, cholic acid, and thiouracil for 12 weeks to induce atherosclerosis, followed by SHT, BT, OL, or simvastatin (positive control, PC) for another 12 weeks. Atherogenicity and oxidative toxicity were assessed via biochemical and histopathological analyses. C18:0 (stearic acid) was the most abundant fatty acid in BT (34.648%), followed by SHT (7.064%) and OL (3.535%). C18:1 (oleic acid) was highest in OL (67.949%), followed by SHT (43.737%) and BT (26.325%). C18:2t + 1 (trans-linoleic acid) was present at 11.434% in OL. AGD induced significant dyslipidemia, oxidative stress, and aortic and cardiac tissue damage in rats. Supplementation with tallow or olive oil significantly reduced total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and C-reactive protein (CRP) levels, whereas the same supplementation significantly increased high-density lipoprotein cholesterol (HDL-C) and total antioxidant (TAO) levels (p < 0.001). Additionally, the atherogenic index (AI) was significantly reduced (p < 0.0001) in all treated groups, indicating protection against hyperlipidemic-induced oxidative stress and atherogenesis. Histopathological analysis revealed partial to evident regression of atherosclerotic changes, with the most pronounced effects observed in the OL group, followed by the SHT and BT groups. The high C18:1 (oleic acid) content in OL and the high C18:0 (stearic acid) content in BT may underlie their cardioprotective effects. OL, SHT, and BT demonstrated lipid-lowering, antioxidant, and anti-inflammatory properties that contributed to the regression of diet-induced atherosclerosis in rats. These findings suggest that both plant-based olive oil and animal-derived tallows may exert cardioprotective effects depending on their fatty acid composition in this rat model of atherogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.