Evidence map›Paper›PMID 41495273›Full record

ArticleJournal of animal science2026

CircACLY regulates proliferation, differentiation, and apoptosis of Jingyuan chicken myoblasts by sponging gga-miR-6660-3P.

Ruimin Ma, Ying Zhou, Weizhen Wang, Ling Zhu, Tong Zhang, Jinli Tian, Lijuan Yang, Hua Wang, Lin Xue, Siyu Chen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruimin MaCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Ying ZhouNingxia Agricultural School, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Weizhen WangCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Ling ZhuCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Tong ZhangCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Jinli TianCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Lijuan YangCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Hua WangCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Lin XueCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Siyu ChenCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Xiaohua TianCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Xiaoyun JiCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Zhengyun CaiCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Yaling GuCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.
Juan ZhangCollege of Animal Science and Technology, Ningxia University, Ningxia Hui Autonomous Region, Yinchuan, 750021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are key gene regulators that are involved in many fundamental biological processes. Skeletal muscle cannot develop normally without the involvement of circRNA. While circRNA plays a pivotal role in skeletal muscle development, its functions and mechanisms within the muscle development of local chicken breeds remain to be thoroughly elucidated. This study, using the Jingyuan chicken as a model, investigated the regulatory role of circACLY in skeletal muscle development and inosine monophosphate (IMP) synthesis. Experiments verified that circACLY is a circRNA that is mainly localized to the cytoplasm. Bioinformatics analysis and experimental validation demonstrated that circACLY is a target of gga-miR-6660-3p, which in turn regulates the expression of Ectonucleotide Triphosphate Diphosphohydrolase 7 (ENTPD7). Functional assays demonstrated that gga-miR-6660-3p inhibits myoblast proliferation and differentiation capacity while suppressing the de novo IMP synthesis pathway. However, circACLY reverses the inhibitory effects of gga-miR-6660-3p on these processes. This study systematically elucidates the regulatory mechanism of the circACLY/gga-miR-6660-3p/ENTPD7 axis in the development of quail myoblasts and IMP synthesis, providing a theoretical basis for deepening the understanding of the molecular basis of skeletal muscle development in local chicken breeds and the genetic improvement of meat quality traits.

Indexed as

ApoptosisCell DifferentiationCell ProliferationChickensMicroRNAsMyoblastsRNA, CircularAnimalsGene Expression RegulationMicroRNAsRNA, CircularapoptosiscircACLYENTPD7gga-miR-6660-3pinosine monophosphate de novo synthesis pathwayproliferation and differentiation

Identifiers

PMID41495273
PMCPMC12988482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.