ArticleNature chemical biology2026
Photo-cross-linking-assisted deorphanization deciphers GPR50-L-LEN pairing in metabolism.
Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.Pharmacological reviews · 2026Review
- Approaches to deorphanize secretome: Classical, computational, and next generation strategies to reveal ligand-receptor networks.EXO : beyond the cell · 2026Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
G-protein-coupled receptors (GPCRs) are transmembrane proteins that transduce extracellular stimuli into intracellular events. While central to physiology and drug discovery, approximately 100 GPCRs remain orphan, limiting insights into their biology. We establish a generalizable photo-cross-linking-assisted GPCR deorphanization platform that leverages site-specifically incorporated photo-cross-linkers for interface-selective ligand capture from native biological samples. We systematically demonstrate the sensitivity, specificity and broad applicability of our system using multiple GPCR-ligand pairs and further deorphanize GPR50 with the neuropeptide Little-LEN (L-LEN) as its endogenous ligand. L-LEN selectively binds GPR50 and modulates cellular activities through downstream Gα
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Registered trials
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