ArticleScientific reports2026
Dissolution and physical characterization of oral nicotine pouch products.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Development of a model to predict nicotine pharmacokinetics from oral nicotine pouches.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we conducted a comprehensive analysis of seven commercially available nicotine pouch products, including on!, Zyn, Velo, Dryft, Rogue, Volt, and Loop nicotine pouches. Analyses include nicotine content, nicotine dissolution release, particle size, imaging (bulk filler and outer pouch material), bulk density (tapped and untapped), true density, crystallinity, solubility, oven volatiles (OV as measured by percent moisture content, % MC), pH of aqueous extracts, water activity, and extract viscosity. The nicotine dissolution profiles showed a faster release for on!, Zyn, and Rogue when compared to Velo, Dryft, Volt, and Loop nicotine pouches. When all nicotine pouches release profiles were compared to on!, only Zyn and Rogue were found equivalent. Particle size analysis revealed Gaussian-like distributions for on!, Rogue, and Zyn nicotine pouches. The remaining products displayed bimodal particle size distributions. Tapped and untapped bulk densities were measured to assess the flowability of the filler in all seven nicotine pouches. Rogue and Loop nicotine pouches exhibited the highest and lowest flowabilities, respectively. Solubility data indicated that Zyn nicotine pouches had the highest percentage of soluble components, whereas Rogue nicotine pouches had the lowest. Rheology results from the nicotine pouch extracts in artificial saliva showed the highest viscosity for Loop and lowest viscosity for Volt and Rogue nicotine pouches. All products were found to have crystalline structures with both high and low temperature melting points. Our results indicate that nicotine pouch products exhibit differences and similarities in their physicochemical properties, providing valuable insights into understanding their formulation and development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.