Evidence map›Paper›PMID 41495124›Full record

ArticleScientific reports2026

Association between blink-related anterior segment dynamics and intraocular pressure.

Vito Ivano D'Alessandro, Filippo Attivissimo, Attilio Di Nisio, Anna Lanzolla, Amal Isaiah, Giuliano Scarcelli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vito Ivano D'AlessandroDepartment of Electric and Information Engineering, Polytechnic University of Bari, Bari, Italy.
Filippo AttivissimoDepartment of Electric and Information Engineering, Polytechnic University of Bari, Bari, Italy.
Attilio Di NisioDepartment of Electric and Information Engineering, Polytechnic University of Bari, Bari, Italy.
Anna LanzollaDepartment of Electric and Information Engineering, Polytechnic University of Bari, Bari, Italy.
Amal IsaiahDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Giuliano ScarcelliFischell Department of Bioengineering, University of Maryland, College Park, MD, USA. scarc@umd.edu.

Funding

TEDCO Maryland Innovation Initiative
6 · The paper itself

Abstract

Intraocular pressure (IOP) is a key parameter for diagnosing and managing glaucoma. This study introduces a novel, non-contact method for evaluating blink-induced anterior segment dynamics, as observed through corneal profile motion during natural blinking, demonstrating its dependence on IOP. The eyelid deforms the corneal surface during a blink, resulting in a rebound response. A high-speed lateral imaging system tracked corneal profile motion in healthy volunteers during the eye-opening phase. Changes in anterior segment dynamics were analyzed at baseline and after the Valsalva maneuver to increase IOP. Two metrics were measured in both conditions: the time constant [Formula: see text], linked to the rebound speed, and the displacement amplitude [Formula: see text], measuring the extent of longitudinal corneal profile displacement. Fifteen participants without ocular disease were enrolled. The longitudinal displacement of the corneal profile revealed faster anterior segment dynamics during the Valsalva maneuver compared to the baseline. We identified a statistically significant difference in [Formula: see text] related to the rebound velocity between the baseline and Valsalva conditions (P < 0.05) but not for [Formula: see text]. The proposed non-contact technique demonstrates sensitivity to IOP variations by analyzing anterior segment dynamics during a natural, complete blink, which supports further assessment of potential home-based, frequent IOP monitoring to prevent glaucoma progression and vision loss.

Indexed as

Anterior Eye SegmentBlinkingIntraocular PressureAdultCorneaFemaleHumansMaleValsalva ManeuverAnterior segment dynamicsEye blinkingEye retractionGlaucomaImage segmentationIntraocular pressure (IOP)

Identifiers

PMID41495124
PMCPMC12858817

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.