Evidence map›Paper›PMID 41495081›Full record

ArticleNPJ vaccines2026

Passive transfer of human sera from chikungunya virus virus-like particle vaccine (Vimkunya) recipients fully protects non-human primates from viremia.

Christopher S Morello, Ravi Anantha, Jason E Comer, Jason Mendy, Lauren C Tindale, Jason S Richardson, Ben Guenther, Nhuxuan Ho, Christopher M Cirimotich, Cassandra Childs O'Connor and 4 more

Abstract read
In one paragraph

Article in NPJ vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christopher S Morello *Bavarian Nordic Inc, Durham, NC, USA.
Ravi Anantha *Emergent BioSolutions, Gaithersburg, MD, USA.
Jason E ComerUniversity of Texas Medical Branch at Galveston, Galveston, TX, USA.
Jason MendyBavarian Nordic Inc, Durham, NC, USA.
Lauren C TindaleBavarian Nordic Canada Inc., Toronto, ON, Canada.
Jason S RichardsonBavarian Nordic Canada Inc., Toronto, ON, Canada. jari@bavarian-nordic.com.
Ben GuentherEmergent BioSolutions, Gaithersburg, MD, USA.
Nhuxuan HoEmergent BioSolutions, Gaithersburg, MD, USA.
Christopher M CirimotichBattelle Biomedical Research Center, West Jefferson, OH, USA.
Cassandra Childs O'ConnorBattelle Biomedical Research Center, West Jefferson, OH, USA.
Deborah M AndersonBavarian Nordic Canada Inc., Toronto, ON, Canada.
Lisa BedellBavarian Nordic Inc, Durham, NC, USA.
Kelly L WarfieldEmergent BioSolutions, Gaithersburg, MD, USA.
Lo VangBavarian Nordic Inc, Durham, NC, USA.

Funding

World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
NIAID NIH HHS R24 AI120942
6 · The paper itself

Abstract

Vimkunya, a chikungunya virus (CHIKV) virus-like particle (VLP) vaccine, is well-tolerated and induces a rapid, durable serum neutralizing antibody (SNA) response in individuals aged ≥12 years. This study evaluated the efficacy of human CHIKV VLP antisera to protect cynomolgus macaques from heterologous CHIKV challenge and determined an SNA titer that confers complete protection against viremia. Macaques receiving negative control sera had detectable viremia and RNAemia, whereas those receiving control anti-CHIKV IgG or CHIKV VLP antisera with pre-challenge NT

Identifiers

PMID41495081
PMCPMC12864846

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.