Evidence map›Paper›PMID 41495042›Full record

ArticleNature communications2026

NTAC: Neuronal type assignment from connectivity.

Gregory Schwartzman, Ben Jourdan, David García-Soriano, Arie Matsliah

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Uncovering Sex Differences in thebioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gregory Schwartzman *Japan Advanced Institute of Science and Technology (JAIST), Nomi, Japan.
Ben Jourdan *University of Edinburgh, Edinburgh, United Kingdom.ORCID http://orcid.org/0000-0001-9831-0098
David García-SorianoUniversitat Politècnica de Catalunya (UPC) & Serra Húnter Fellow, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2869-9330
Arie MatsliahPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA. arie@princeton.edu.ORCID http://orcid.org/0009-0001-4490-2028

Funding

Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
Accelerating connectomic proofreading for larger brains and multiple individualsRF1MH129268 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA · 2022 to 2022
$2.1M
NIMH NIH HHS RF1 MH117815NIMH NIH HHS RF1 MH129268NINDS NIH HHS U24 NS126935
6 · The paper itself

Abstract

Recent advances in electron microscopy and computer vision now allow the reconstruction of complete wiring diagrams, or connectomes, of animal brains. This creates an urgent need for methods that can automatically identify neuronal cell types directly from these large connectivity datasets. Here we show that synaptic connectivity alone can be used to assign neurons to cell types with high accuracy. We introduce NTAC (Neuronal Type Assignment from Connectivity), which groups neurons based only on connectivity. NTAC has two forms: a semi-supervised one that leverages a small fraction of labeled neurons to infer the types of all others, and an unsupervised one that requires no labels at all. Applied to multiple state-of-the-art fruit fly brain connectomes, NTAC achieves high accuracy within only minutes on a laptop, demonstrating that connectivity provides a powerful and scalable basis for classifying neuronal cell types across the brain.

Indexed as

BrainConnectomeNeuronsAnimalsDrosophila melanogasterSynapses

Identifiers

PMID41495042
PMCPMC12868737

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.