ArticleNature communications2026
Stress-trained microalgae robots with probiotics backpack and intestinal brake for inflammatory bowel disease management.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Analysis of clinical characteristics and bronchoalveolar lavage fluid microbial community diversity in non-cystic fibrosis bronchiectasis patients withMicrobiology spectrum · 2026Article
- Single-cell transcriptomics-guided dynamic hydrogel delivery of artemisia argyi-derived EVs relieves ER stress and promotes diabetic wound regeneration.Journal of nanobiotechnology · 2026Article
- Enzyme/Reactive Oxygen Species-Dually Activated Hyaluronic Acid Nanocarriers Enable Celastrol Delivery for Site-Specific Therapy of Inflammatory Bowel Diseases and Colorectal Cancer.International journal of nanomedicine · 2026Article
- NEAT1 modulates neutrophil functions via glycolysis to restrain mucosal inflammation in ulcerative colitis.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Inflammatory bowel disease (IBD) involves elevated intestinal reactive oxygen species (ROS) and microbial imbalance. A key challenge is that current delivery systems cannot adequately protect active agents, such as antioxidants and probiotics, through the harsh gastric environment nor precisely deliver them to inflamed intestinal sites. Here, we present the EcN@PDA@HP biohybrid robot, composed of stress-trained microalgae, probiotics, and an intestinal braking system, enabling rapid gastric passage and precise retention in inflamed regions. Stress-trained Haematococcus pluvialis (HP) developed a thickened cell wall for gastric resilience, maintained flagella-driven motility, and enhanced astaxanthin (AST) production. Polydopamine (PDA)-coated Escherichia coli Nissle 1917 (EcN) anchors onto HP via host-guest interactions. In vivo, PDA preserves EcN activity and enables specific adhesion to inflamed sites. By combining antioxidizing AST and bacteriotherapy, EcN@PDA@HP effectively alleviates male murine IBD models via ROS scavenging and microbiota restoration, offering a promising strategy for diverse IBD conditions.
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Registered trials
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