Evidence map›Paper›PMID 41495018›Full record

ArticleNature communications2026

Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N

Zhenyu Yang, Weining Sun, Qiao Huang, Yueyue Li, Meng Yuan, Yu Yang, Heng Zhao, Zheyi Liu, Xiaoxi Zeng, Fangjun Wang and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The mCells · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhenyu Yang *West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-0633-8710
Weining Sun *Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Qiao Huang *Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yueyue Li *Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Meng YuanDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yu YangInnovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Heng ZhaoState Key Laboratory of Chemical Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Zheyi LiuState Key Laboratory of Chemical Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Xiaoxi ZengWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-9946-4291
Fangjun WangState Key Laboratory of Chemical Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.ORCID 0000-0002-8118-7019
Yuanyuan JiangDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China. yyjiang@scu.edu.cn.ORCID 0000-0001-8594-6046
Yi ZhaoWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. biozy@ict.ac.cn.ORCID 0000-0001-6046-8420
Runsheng ChenWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. crs@ibp.ac.cn.

Funding

China Postdoctoral Science Foundation 2024M752190National Natural Science Foundation of China (National Science Foundation of China) 82404409National Natural Science Foundation of China (National Science Foundation of China) 82404514Natural Science Foundation of Sichuan Province
6 · The paper itself

Abstract

YTHDC2, a unique YTH-domain-containing protein that recognizes N6-methyladenosine (m

Indexed as

AdenosineDeep LearningDrug DiscoveryRNA-Binding ProteinsHumansRNARNA HelicasesRNA, MessengerAdenosineN-methyladenosineRNARNA-Binding ProteinsRNA HelicasesRNA, MessengerYTHDC2 protein, human

Identifiers

PMID41495018
PMCPMC12775497

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.