Trial reportBMJ paediatrics open2026
Effects of Kangaroo care during retinopathy screening examination: a randomised clinical trial.
Trial report in BMJ paediatrics open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveProviding Kangaroo care (K-care) helps comfort infants through painful and stressful procedures including retinopathy screening examination (RSE) for retinopathy of prematurity. We examined the early pain-related and delayed inflammatory effects of K-care during the first RSE in preterm infants.
designRandomised clinical trial.
settingIn a family-centred neonatal intensive care unit between 1 March 2023 and 31 August 2024. PATIENTS: Preterm infants (gestation <34+0 weeks and/or birth weight <2000 g) who required RSEs.
interventionsPatients were randomly assigned to K-care provided by mother or father during RSE or control group on an examination table (n=50/group).
main outcome measuresThe Premature Infant Pain Profile (PIPP) score within the first minute of RSE was measured. Salivary samples (>110 uL) were collected before, at 1 and 6-8 hours after RSE for assays of cortisol, interleukin-1β, interleukin-6 and tumour necrosis factor-alpha (TNF-α) levels by ELISA methods in a blinded fashion.
results100 infants (mean±SD gestational age: 31.1±2.4 weeks; birth weight: 1496±452 g, 58% males) were enrolled. Compared with controls (n=50), infants of the K-care group (n=50) had significantly lower PIPP score (11.0 vs 12.9; p=0.002); salivary cortisol levels (4.9 vs 6.9 ng/mL; p=0.001) at 1 hour after RSE, interleukin-6 (31.9 vs 34.7 pg/mL; p=0.01) and TNF-α (53.9 vs 58.6 pg/mL; p=0.02), but not interleukin-1β (50.4 vs 53.0 pg/mL; p=0.46), levels at 6-8 hour after RSE.
conclusionsProviding K-care during RSE in preterm infants may potentially reduce pain-related stress, cortisol and inflammatory responses.
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