ArticleAmerican journal of physiology. Endocrinology and metabolism2026
Twelve weeks of voluntary wheel running restores glucagon sensitivity in middle-aged mice.
Article in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Glyoxalase 1 loss reduces fatty liver but impairs glucose handling in male mice.Physiological reports · 2026Article
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Abstract
Aerobic exercise training is a potent intervention for the treatment and prevention of age-related metabolic disease, which is characterized by both insulin and glucagon resistance. Although insulin resistance is a key driver of metabolic disease in aging, glucagon signaling is equally critical in maintaining both glucose and lipid homeostasis, particularly during exercise. Previous studies have established the glucagon-sensitizing effects of exercise training in younger animals. Most studies in rodents use rigorous and carefully dosed forced exercise protocols. This forced exercise is a stressful paradigm. We implemented a voluntary wheel running (VWR) intervention to assess the effects of aging and exercise training on glucagon sensitivity. We initiated 12-wk of VWR in young adult (6-mo-old) and middle-aged (12-mo-old) C57BL/6NCrl male mice. Glucagon sensitivity, as assessed by glucagon-stimulated hyperglycemia, was decreased in middle-aged compared with young adult sedentary mice (
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