Evidence map›Paper›PMID 41494653›Full record

ArticleJournal of the American Chemical Society2026

Phosphoglycerate Kinase Can Adopt Topologically Misfolded Forms That Are More Stable Than Its Native State.

Yingzi Xia, Barbara T Amann, Richard E Gillilan, Yang Jiang, Piyoosh Sharma, Sreemantee Sen, Karen G Fleming, Edward P O'Brien, Stephen D Fried

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yingzi XiaDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Barbara T AmannT. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Richard E GillilanCenter for High Energy X-ray Sciences (CHEXS), Ithaca, New York 14853, United States.
Yang JiangDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0003-1100-9177
Piyoosh SharmaDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Sreemantee SenDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Karen G FlemingT. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0001-5417-8830
Edward P O'BrienDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0001-9809-3273
Stephen D FriedDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0003-2494-2193

Funding

Translation Kinetics and their Effects on Protein Structure and Function, mRNA half-lives, and Cellular PhenotypeR35GM124818 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Edward Patrick O'Brien · 2017 to 2026
$4.0M
Watching Proteins Fold (or Misfold) in vivo with Mass SpectrometryDP2GM140926 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FRIED, STEPHEN DAVID · 2020 to 2020
$2.3M
NIGMS NIH HHS DP2 GM140926NIGMS NIH HHS R35 GM124818
6 · The paper itself

Abstract

The native states of globular proteins are typically viewed as being the most stable conformations on their respective proteins' soluble free energy landscapes. This view, known as the thermodynamic hypothesis, explains why many proteins can reversibly refold after being denatured. Here we report an intriguing counterexample to this paradigm. When

Indexed as

Escherichia coliPhosphoglycerate KinaseProtein FoldingKineticsModels, MolecularProtein ConformationProtein DenaturationProtein StabilityThermodynamicsPhosphoglycerate Kinase

Identifiers

PMID41494653
PMCPMC13263995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.