Evidence map›Paper›PMID 41494644›Full record

ArticlePhysiological genomics2026

Multiomics alterations associated with tolerance and response to simulated progressive hemorrhage in healthy adult humans.

Burook Misganaw, Seid Muhie, Aarti Gautam, Stacy-Ann Miller, Ida Nela Crespo Rosales, George I Dimitrov, Bintu Sowe, Christopher P Johnson, Shelly K Roberts, Riley J Regimbal and 5 more

Abstract read
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In one paragraph

Article in Physiological genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Burook MisganawMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.ORCID 0000-0002-9569-1662
Seid MuhieMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.ORCID 0000-0003-3409-049X
Aarti GautamMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.
Stacy-Ann MillerMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.
Ida Nela Crespo RosalesMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.
George I DimitrovMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.
Bintu SoweMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.
Christopher P JohnsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Shelly K RobertsDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Riley J RegimbalDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Chad C WigginsDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-6458-0142
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-7135-7643
Timothy B CurryDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Victor A ConvertinoUS Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, Texas, United States.
Rasha HammamiehMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.ORCID 0000-0001-8643-6232

Funding

DOD | MHS | Congressionally Directed Medical Research Programs (CDMRP) DM180240
6 · The paper itself

Abstract

Hemorrhagic shock is a leading cause of preventable death among military and civilian trauma patients. Although caused by severe hypovolemia, the threshold of blood volume reduction that triggers recruitment of compensatory mechanisms varies markedly. Individuals have been classified as having low tolerance (LT) or high tolerance (HT) to hypovolemia; however, molecular features contributing to tolerance remain unclear. Here we investigate multiomics correlates of hypovolemia tolerance and molecular responses underlying physiological compensating mechanisms of blood loss. Healthy adult human subjects (

Indexed as

HemorrhageHypovolemiaShock, HemorrhagicAdultFemaleHealthy VolunteersHemodynamicsHumansLower Body Negative PressureMaleMicroRNAsMiddle AgedMultiomicsRNA, MessengerTranscriptomeYoung AdultMicroRNAsRNA, MessengergenomicshemorrhageLBNPmultiomicstrauma

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.