Evidence map›Paper›PMID 41494593›Full record

ReviewMolecules and cells2026

Viral transduction for T cell engineering in immunotherapy.

Yikhyeon Seo, Jimin Pak, Jiyun Han, Joonbeom Bae, Soo Seok Hwang

Abstract readReview
In one paragraph

Review in Molecules and cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yikhyeon SeoSchool of Biological Sciences, Seoul National University, Gwanak-ro 1, Seoul 08826, Republic of Korea; Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Seoul 08826, Republic of Korea. Electronic address: ssoyik7239@snu.ac.kr.
Jimin PakSchool of Biological Sciences, Seoul National University, Gwanak-ro 1, Seoul 08826, Republic of Korea; Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Seoul 08826, Republic of Korea. Electronic address: jimin0130@snu.ac.kr.
Jiyun HanSchool of Biological Sciences, Seoul National University, Gwanak-ro 1, Seoul 08826, Republic of Korea; Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Seoul 08826, Republic of Korea. Electronic address: hanjy97@snu.ac.kr.
Joonbeom BaeDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address: joonbeombae@korea.ac.kr.
Soo Seok HwangSchool of Biological Sciences, Seoul National University, Gwanak-ro 1, Seoul 08826, Republic of Korea; Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Seoul 08826, Republic of Korea. Electronic address: sshwang@snu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral transduction of primary T cells enables stable genetic engineering for research and immunotherapy, supporting both transgene overexpression and gene deletion. Although the overall workflow can be similar to transduction in other mammalian cell lines, primary T cell culture imposes distinct requirements such as cell-state-dependent nuances shaped by T cell activation and proliferation, which can make it challenging to obtain a sufficient number of genetically engineered T cells. This article provides practical guidance for researchers new to T cells but familiar with basic mammalian cell culture.

Indexed as

Cell EngineeringImmunotherapyT-LymphocytesTransduction, GeneticAnimalsGenetic EngineeringHumansCAR-TImmunotherapyLentiviral transductionRetroviral transductionT cell engineering

Identifiers

PMID41494593
PMCPMC12856448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.