Evidence map›Paper›PMID 41494040›Full record

ArticlePLoS pathogens2026

piR-bmo-796514 facilitates the proliferation of exogenous DNA virus (baculovirus) by targeting the host E3 ubiquitin ligase RNF181.

Junming Xia, Shigang Fei, Wenjie Luo, Mingyang Zhou, Yibing Kong, Yigui Huang, Luc Swevers, Min Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junming XiaGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, Guangdong Engineering Technology Research Center of Sericulture, College of Animal Science, South China Agricultural University, Guangzhou, China.
Shigang FeiGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, Guangdong Engineering Technology Research Center of Sericulture, College of Animal Science, South China Agricultural University, Guangzhou, China.
Wenjie LuoGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, Guangdong Engineering Technology Research Center of Sericulture, College of Animal Science, South China Agricultural University, Guangzhou, China.
Mingyang ZhouGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, Guangdong Engineering Technology Research Center of Sericulture, College of Animal Science, South China Agricultural University, Guangzhou, China.
Yibing KongGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, Guangdong Engineering Technology Research Center of Sericulture, College of Animal Science, South China Agricultural University, Guangzhou, China.
Yigui HuangGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, Guangdong Engineering Technology Research Center of Sericulture, College of Animal Science, South China Agricultural University, Guangzhou, China.
Luc SweversInsect Molecular Genetics and Biotechnology, National Centre for Scientific Research Demokritos, Institute of Biosciences and Applications, Athens, Greece.
Min FengGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, Guangdong Engineering Technology Research Center of Sericulture, College of Animal Science, South China Agricultural University, Guangzhou, China.ORCID https://orcid.org/0000-0001-6427-3612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PIWI-interacting RNAs (piRNAs), a class of 23-31 nucleotide non-coding RNAs, are known for silencing transposons and endogenous retroviruses that reside in animal genomes. However, the mechanisms by which host piRNAs affect exogenous viral infections, particularly those by DNA viruses, remain poorly understood. Here, we demonstrated that infection by Bombyx mori nucleopolyhedrovirus (BmNPV), a large DNA virus, induced significant upregulation of silkworm host piR-bmo-796514, which facilitated viral proliferation by suppressing the expression of E3 ubiquitin ligase RNF181. We further revealed that RNF181 exerted antiviral activity through ubiquitin-mediated degradation of Integrin α2b-like, a cellular membrane protein that interacted with viral GP64 protein to mediate BmNPV entry. This study unveiled a previously unrecognized regulatory axis connecting host derived piRNAs with exogenous DNA virus infection, providing further mechanistic insights into the modulation of exogenous viral pathogenesis through the reprogramming of the piRNA pathway. Our findings not only advance the understanding of the immune escape mechanism of exogenous viruses but also provide new insights for the development of oligonucleotide antiviral drugs that target proviral piRNAs.

Indexed as

BombyxInsect ProteinsNucleopolyhedrovirusesRNA, Small InterferingUbiquitin-Protein LigasesAnimalsVirus ReplicationInsect ProteinsRNA, Small InterferingUbiquitin-Protein Ligases

Identifiers

PMID41494040
PMCPMC12799189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.