Evidence map›Paper›PMID 41493894›Full record

ArticleJournal of the International Association of Providers of AIDS Care

Implementation of Daily Oral PrEP at HIV/AIDS Service Organizations in Lima, Peru: Early Findings From the PrEP PERU Demonstration Study.

Pamela Ramírez, Alexander J Lankowski, Jorge A Gallardo-Cartagena, Pedro Gonzales, Javier Valencia, Javier R Lama, Mey León, Javier Salvatierra, Hugo Sanchez, Robinson Cabello and 3 more

Abstract read
In one paragraph

Article in Journal of the International Association of Providers of AIDS Care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pamela RamírezCentro de Investigaciones Tecnológicas, Biomédicas y Medioambientales, Universidad Nacional Mayor de San Marcos, Lima, Peru.ORCID 0000-0002-1144-0138
Alexander J LankowskiFred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-4769-7242
Jorge A Gallardo-CartagenaCentro de Investigaciones Tecnológicas, Biomédicas y Medioambientales, Universidad Nacional Mayor de San Marcos, Lima, Peru.ORCID 0000-0001-5142-1954
Pedro GonzalesAsociación Civil Impacta Salud y Educación, Lima, Peru.ORCID 0000-0002-2610-0136
Javier ValenciaAsociación Civil Impacta Salud y Educación, Lima, Peru.ORCID 0000-0002-3635-1107
Javier R LamaAsociación Civil Impacta Salud y Educación, Lima, Peru.ORCID 0000-0002-4983-5725
Mey LeónAsociación Civil Impacta Salud y Educación, Lima, Peru.ORCID 0000-0003-3713-4902
Javier SalvatierraEpicentro, Lima, Peru.ORCID 0000-0002-9802-1330
Hugo SanchezEpicentro, Lima, Peru.ORCID 0000-0002-6876-2824
Robinson CabelloAsociación Civil Vía Libre, Lima, Peru.ORCID 0000-0003-4765-0548
Kelika A KondaKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-2836-0174
Jorge L SanchezCentro de Investigaciones Tecnológicas, Biomédicas y Medioambientales, Universidad Nacional Mayor de San Marcos, Lima, Peru.ORCID 0000-0001-6020-8266
PrEP PERU Study Group

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
NIAID NIH HHS P30 AI027757
6 · The paper itself

Abstract

BackgroundDespite global declines in HIV incidence, new infections continue to rise in Latin America. Oral tenofovir-based HIV pre-exposure prophylaxis (PrEP) is effective and can reduce incidence where implemented. PrEP PERU is a prospective cohort study evaluating daily oral PrEP delivery at HIV/AIDS service organizations (ASOs) in Peru.MethodsWe assessed 12-month PrEP retention and adherence among men who have sex with men (MSM) enrolled at 4 ASOs in Lima before the COVID-19 pandemic. The analysis included participants with ≥12 months of follow-up before the March 2020 lockdown. Follow-up visits occurred at weeks 4, 12, and quarterly thereafter. We used robust Poisson regression to evaluate associations between baseline characteristics and 2 outcomes: retention (attending ≥3 follow-up visits within 12 months) and optimal adherence (proportion of days covered ≥80%).ResultsAmong 264 MSM who initiated PrEP, median age was 31 years (IQR: 27-37). Retention at 12 months was 71%, and 55% achieved optimal adherence. Retention was associated with age ≥30 and bisexual identity in adjusted models. Optimal adherence was associated with being employed at baseline.ConclusionsPrEP delivery through ASOs in Lima is feasible and supports sustained engagement among MSM. Targeted strategies are needed to improve outcomes among younger individuals.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisTenofovirAdministration, OralAdultCOVID-19Homosexuality, MaleHumansMaleMedication AdherencePeruProspective StudiesAnti-HIV AgentsTenofovirHIV preventionimplementation scienceLatin Americamen who have sex with menPeruPrEP adherencePrEP retention

Identifiers

PMID41493894
PMCPMC12775336

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.