Evidence map›Paper›PMID 41493775›Full record

ArticleACS applied materials & interfaces2026

Cellular Uptake of Nanoparticles is Regulated by Integrin-Based Adhesion to the Extracellular Matrix.

Sailesti Joshi, Ananya Naha, Justice Ene, Christina Holmes, Yan Li, Tristan Driscoll

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sailesti JoshiDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer Street, Tallahassee, Florida 32310, United States.
Ananya NahaDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer Street, Tallahassee, Florida 32310, United States.
Justice EneDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer Street, Tallahassee, Florida 32310, United States.
Christina HolmesDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer Street, Tallahassee, Florida 32310, United States.
Yan LiDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer Street, Tallahassee, Florida 32310, United States.
Tristan DriscollDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer Street, Tallahassee, Florida 32310, United States.ORCID 0000-0002-2426-5551

Funding

Engineering Extracellular Vesicles of Human Brain Organoids for Stroke TherapyR01NS125016 · NINDS · FLORIDA STATE UNIVERSITY · PI Yan Li · 2022 to 2026
$1.8M
Quantitative Molecular Imaging in Engineered Cellular Microenvironments to Study and Control Directional MechanosensingR35GM155264 · NIGMS · FLORIDA STATE UNIVERSITY · PI Tristan P Driscoll · 2024 to 2026
$1.1M
Engineering Surface Coatings for Localized Delivery of Therapeutic Extracellular VesiclesR16GM151369 · NIGMS · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI HOLMES, CHRISTINA ANDREA · 2023 to 2023
$171k
NIGMS NIH HHS R16 GM151369NIGMS NIH HHS R35 GM155264NINDS NIH HHS R01 NS125016
6 · The paper itself

Abstract

Therapeutic nanoparticle delivery is crucial for a variety of biomedical applications, such as immunizations, gene and drug delivery, tissue engineering, biomedical implant coating, and other regenerative medicine approaches. The uptake of therapeutic nanoparticles occurs through several endocytosis pathways. However, the uptake mechanism of nanoparticles delivered from a substrate is also regulated by cell-substrate interactions and the ability of cells to mechanosense their surrounding extracellular matrix (ECM). These cell-ECM interactions influence integrin signaling, focal adhesion formation, and cytoskeletal rearrangement to impact nanoparticle uptake. In this study, we investigated the role of ECM and ECM-mimetic coatings─collagen I (COL), fibronectin (FN), laminin (LM), hyaluronic acid (HA), and poly-l-lysine (PLL)─on the uptake of poly(lactic-

Indexed as

Extracellular MatrixIntegrinsNanoparticlesAnimalsCell AdhesionHyaluronic AcidMiceNIH 3T3 CellsPolylactic Acid-Polyglycolic Acid CopolymerRatsRAW 264.7 CellsHyaluronic AcidIntegrinsPolylactic Acid-Polyglycolic Acid Copolymercytoskeletonendocytosisextracellular matrixintegrin-based adhesionsnanoparticle uptake

Identifiers

PMID41493775
PMCPMC12867119

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.