Evidence map›Paper›PMID 41493709›Full record

ArticleProbiotics and antimicrobial proteins2026

Alleviating Mechanism of Microencapsulated Compound Probiotics Against Obesity via PPAR Metabolic Pathway.

Yuying Ma, Shuqin Yan, Yan Dong, Yue Ma, Xingli Lai, Xinyuan Jin, Lili Huang, Qingshen Sun

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuying Ma *Engineering Research Center of Agricultural Microbiology Technology, Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology, College of Heilongjiang Province & School of Life Sciences, Ministry of Education, Heilongjiang University, Harbin, 150080, China.
Shuqin Yan *Engineering Research Center of Agricultural Microbiology Technology, Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology, College of Heilongjiang Province & School of Life Sciences, Ministry of Education, Heilongjiang University, Harbin, 150080, China.
Yan DongEngineering Research Center of Agricultural Microbiology Technology, Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology, College of Heilongjiang Province & School of Life Sciences, Ministry of Education, Heilongjiang University, Harbin, 150080, China.
Yue MaEngineering Research Center of Agricultural Microbiology Technology, Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology, College of Heilongjiang Province & School of Life Sciences, Ministry of Education, Heilongjiang University, Harbin, 150080, China.
Xingli LaiEngineering Research Center of Agricultural Microbiology Technology, Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology, College of Heilongjiang Province & School of Life Sciences, Ministry of Education, Heilongjiang University, Harbin, 150080, China.
Xinyuan JinEngineering Research Center of Agricultural Microbiology Technology, Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology, College of Heilongjiang Province & School of Life Sciences, Ministry of Education, Heilongjiang University, Harbin, 150080, China.
Lili HuangCollege of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China. huanglili@hljucm.edu.cn.
Qingshen SunEngineering Research Center of Agricultural Microbiology Technology, Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology, College of Heilongjiang Province & School of Life Sciences, Ministry of Education, Heilongjiang University, Harbin, 150080, China. kejiansqs@163.com.ORCID http://orcid.org/0000-0001-7282-4330

Funding

Natural Science Foundation of Heilongjiang Province LH2021C075
6 · The paper itself

Abstract

Obesity is a global health challenge, but current pharmacological interventions (e.g., orlistat) often cause adverse effects. Although probiotics show potential in alleviating obesity, the mechanisms by which microencapsulated compound probiotics exert anti-obesity effects via peroxisome proliferator-activated receptors (PPARs) remain unclear. Our previous study demonstrated that pectin beads encapsulating compound probiotics (Lactiplantibacillus plantarum, Limosilactobacillus fermentum, Bifidobacterium breve) exhibited superior anti-obesity effects to single strain in high-fat diet (HFD)-fed rats. Here, we systematically investigated the alleviating effects of these microencapsulated compound probiotics (1 × 10⁸ CFU/day, oral gavage) against HFD-induced obesity in C57BL/6J mice (8-wk intervention) via PPARs-mediated regulatory mechanisms, with orlistat (24 mg·kg

Indexed as

ObesityPeroxisome Proliferator-Activated ReceptorsProbioticsAnimalsDiet, High-FatDrug CompoundingMaleMiceMice, Inbred C57BLPeroxisome Proliferator-Activated ReceptorsCompound probioticsGut microbiotaObesityPPARsPrevention

Identifiers

PMID41493709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.