Evidence map›Paper›PMID 41493622›Full record

SynthesisArchives of orthopaedic and trauma surgery2026

The postoperative analgesic efficacy of three peripheral nerve blocks in hip fracture surgery: a systematic review and meta-analysis of randomised trials.

Kaja Vermazen, Anna Niblett, Chloe Thomson, Alexandra Tebbett

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Archives of orthopaedic and trauma surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kaja VermazenWarwick Medical School, University of Warwick, Coventry, UK. k.vermazen@doctors.org.uk.
Anna NiblettWarwick Medical School, University of Warwick, Coventry, UK.
Chloe ThomsonOxford University Hospitals NHS Trust, Oxford, UK.
Alexandra TebbettWarwick Medical School, University of Warwick, Coventry, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAnaesthesia for hip fracture surgery is often supplemented with a peripheral nerve block (PNB) to reduce postoperative pain. Common PNBs include fascia-iliaca compartment block (FICB) and femoral nerve block (FNB). Since the introduction of the pericapsular nerve group (PENG) block, debate continues as to which technique provides superior analgesia. This review aimed to compare the postoperative analgesic efficacy of three PNBs when administered perioperatively to adult hip fracture patients.

methodsCINAHL, Cochrane CENTRAL, Embase, Medline, Web of Science and Google Scholar were searched in April 2025. Statistical analysis was performed using a random-effects model.

results19 randomised trials (1059 patients) were included. Pain scores between PENG and FICB at 6, 12 and 24 h were not significantly different. Compared to FNB, PENG significantly lowered pain scores at 6 h (P = 0.004). Opioid consumption in the 24 h postoperative period was significantly lower in PENG than FICB (P = 0.02), but not in FNB. No outcome reached the minimal clinically important difference. Evidence was graded very low to moderate.

conclusionThere is insufficient evidence to state superiority of PENG over FICB or FNB when used perioperatively in patients undergoing hip fracture repair. No included studies reported time to mobilisation, highlighting a significant evidence gap in existing primary research. Further high-quality, sufficiently powered randomised trials are still needed.

Indexed as

Hip FracturesNerve BlockPostoperative PainHumansRandomized Controlled Trials as TopicHip fractureOrthopaedic surgeryPeripheral nerve blockPostoperative painRegional anaesthesia

Identifiers

PMID41493622
PMCPMC12775034

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.