Evidence map›Paper›PMID 41493602›Full record

ArticleJournal of neurology2026

Efficacy and safety of single-trajectory posterior subthalamic area and subthalamic nucleus deep brain stimulation for dystonic tremor: a retrospective pilot study.

Jianyi Shen, Zhengyu Lin, Suzhen Lin, Peng Huang, Yixin Pan, Bomin Sun, Jianqing Ding, Yiwen Wu, Dianyou Li

Abstract read
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In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jianyi ShenInstitute of Aging & Tissue Regeneration, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhengyu LinDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.
Suzhen LinDepartment of Neurology & Institute of Neurology, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.
Peng HuangDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.
Yixin PanDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.
Bomin SunDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.
Jianqing DingInstitute of Aging & Tissue Regeneration, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yiwen WuDepartment of Neurology & Institute of Neurology, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China. ldy11483@rjh.com.cn.
Dianyou LiDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China. wyw11380@rjh.com.cn.ORCID http://orcid.org/0000-0003-4212-4231

Funding

Shanghai Health and Family Planning Commission research project 201840001Shanghai Youth Science and Technology Talents Sailing projects 23YF1424000Youth Project of National Science Foundation of China 82301664
6 · The paper itself

Abstract

objectiveTo evaluate the feasibility, safety, and preliminary efficacy of a novel single-lead, dual-target deep brain stimulation (DBS) approach targeting the posterior subthalamic area (PSA) and subthalamic nucleus (STN) for dystonic tremor.

methodsThis retrospective pilot study reviewed outcomes of six consecutive patients with medically refractory dystonic tremor who underwent single-lead PSA-STN DBS at our center (June-December 2024). Clinical outcomes were assessed using the BFMDRS and FTMTRS scales. A formal blinded crossover assessment was performed in three patients to compare PSA-only, STN-only, and combined stimulation. Chronic settings were selected via patient-directed optimization.

resultsAll six patients completed follow-up (100% retention) and achieved stable chronic stimulation programs. Five patients (83.3%) independently selected combined PSA + STN stimulation; one preferred STN-only. At LFU (6-12 months postoperatively), the mean BFMDRS-Motor score decreased by 78.1% and FTMTRS by 87.1%. The crossover assessment (n = 3) showed that combined stimulation outperformed single-target stimulation. No serious adverse events occurred. All efficacy analyses are exploratory.

conclusionThis single-lead, dual-target PSA-STN DBS approach demonstrates feasibility and preliminary efficacy for dystonic tremor. Prospective controlled trials are warranted.

Indexed as

Deep Brain StimulationDystonic DisordersOutcome Assessment, Health CareSubthalamic NucleusTremorAdultAgedFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsRetrospective StudiesTreatment OutcomeDeep brain stimulationDystonic tremorPosterior subthalamic areaSubthalamic nucleus

Identifiers

PMID41493602
PMCPMC12775118

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.