Evidence map›Paper›PMID 41493502›Full record

ArticleJournal of muscle research and cell motility2026

A single S-ketamine injection enhances mTOR signaling in rat skeletal muscle.

Søren Andersen Skriver, Shokouh Arjmand, Andreas Breenfeldt Andersen, Gregers Wegener, Mette Hansen

Abstract read
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In one paragraph

Article in Journal of muscle research and cell motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Søren Andersen SkriverExercise Biology, Department of Public Health, Aarhus University, Dalgas Avenue 4, Aarhus C, 8000, Denmark. soesk@ph.au.dk.
Shokouh ArjmandTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Andreas Breenfeldt AndersenExercise Biology, Department of Public Health, Aarhus University, Dalgas Avenue 4, Aarhus C, 8000, Denmark.
Gregers WegenerTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Mette HansenExercise Biology, Department of Public Health, Aarhus University, Dalgas Avenue 4, Aarhus C, 8000, Denmark. mhan@ph.au.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

S-ketamine is recognized as a rapid-acting antidepressant, exerting its effects primarily through activation of the mTOR signaling pathway in the brain, which plays a key role in neuroplasticity. Given the shared molecular mechanisms between brain and skeletal muscle, we investigated whether S-ketamine can also modulate regulatory proteins involved in muscle protein synthesis (MPS) and muscle protein breakdown (MPB) in skeletal muscle. Adult female Flinders Sensitive Line rats received a single intraperitoneal injection of S-ketamine (20 mg/kg) or saline, and soleus and extensor digitorum longus (EDL) muscles were collected two hours post-injection for protein analysis using Western blot. S-ketamine significantly increased phosphorylated mTOR (p-mTOR

Indexed as

KetamineMuscle, SkeletalSignal TransductionTOR Serine-Threonine KinasesAnimalsFemaleMuscle ProteinsRatsKetaminemTOR protein, ratMuscle ProteinsTOR Serine-Threonine KinasesAnimal dataAntidepressantsMTOR-signalingProtein metabolismSkeletal muscle.

Identifiers

PMID41493502

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.