Evidence map›Paper›PMID 41493341›Full record

ArticleMicrobiology spectrum2026

Pathogenicity and transmissibility of Mpox virus in African dormice.

Zhaoliang Chen, Lei Zhang, Linzhi Li, Mingjie Shao, Zongzheng Zhao, Chao Shang, Zirui Liu, Juxiang Liu, Yan Liu, Xiao Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhaoliang ChenState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.
Lei ZhangState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.
Linzhi LiState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.
Mingjie ShaoState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.
Zongzheng ZhaoState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.
Chao ShangState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.
Zirui LiuState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.
Juxiang LiuCollege of Veterinary Medicine, Hebei Agricultural University, Baoding, Hebei, China.
Yan LiuState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.ORCID 0009-0006-6359-2615
Xiao LiState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.ORCID 0009-0004-0765-475X
Zhendong GuoState Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.ORCID 0000-0001-8705-7744

Funding

National Key Research and Development Program of China 2023YFD1800403
6 · The paper itself

Abstract

The global spread of Mpox virus (MPXV) poses a major public health challenge, yet reliable and consistent animal models for MPXV evaluation remain limited, which hinders progress in developing treatment strategies and transmission-blocking technologies. As natural hosts, African dormice ( IMPORTANCE: The global spread of monkeypox virus (MPXV) clade IIb has highlighted the urgent need for reliable animal models to investigate its biological characteristics. This study established an African dormouse (Graphiurus spp.) model and systematically characterized the pathogenicity and transmissibility of a clade IIb strain (hMPXV/China/GZ8H-01/2023). Intranasal inoculation induced significant weight loss, lethal infections, and multi-organ pathology, with robust viral replication in the respiratory and liver tissues. Direct contact transmission was efficient: 1/3 of contact-exposed dormice shed infectious virus, while 2/3 showed seropositivity. Although airborne exposure resulted in 1/3 seropositivity, no infectious virus was detected, thereby indicating limited airborne transmission. Infected dormice emitted abundant virus-laden aerosols, peaking at 3.78 ± 1.01×10⁶ copies/dormouse/hour at 12 days post-infection (dpi). These findings establish African dormice as effective models for studying MPXV infection, pathogenicity, and transmission. Enhanced surveillance of wild dormouse populations is critical due to their potential role in MPXV transmission chains.

Indexed as

Monkeypox virusMpox, MonkeypoxAnimalsDisease Models, AnimalVirulenceVirus ReplicationVirus Sheddingairborne transmissioncontact transmissiondormiceMpox viruspathogenicity

Identifiers

PMID41493341
PMCPMC12889042

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.