Article in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Andrzej W CwetschUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team Genetics and Development of the Cerebral Cortex, 75014 Paris, France.ORCID 0000-0002-8156-1218
Sofia FerreiraUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team Genetics and Development of the Cerebral Cortex, 75014 Paris, France.ORCID 0000-0003-2066-6865
Elodie DelbergheUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team Genetics and Development of the Cerebral Cortex, 75014 Paris, France.
Javier Gilabert-JuanDepartamento de Anatomía, Histología y Neurociencia, Universidad Autónoma de Madrid, 28039 Madrid, Spain.ORCID 0000-0001-5187-3942
Matthieu X MoreauUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team Genetics and Development of the Cerebral Cortex, 75014 Paris, France.ORCID 0000-0002-2592-2373
Yoann SaillourUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team Genetics and Development of the Cerebral Cortex, 75014 Paris, France.ORCID 0000-0002-5110-9239
Pau García-BoluferDepartamento de Biología Celular, Biología Funcional y Antropología Física, Instituto de Biotecnologia y Biomedicina (BIOTECMED), Universidad de Valencia, 46100 Burjassot, Spain.ORCID 0000-0001-6553-5696
Saray Calvo-ParraDepartamento de Biología Celular, Biología Funcional y Antropología Física, Instituto de Biotecnologia y Biomedicina (BIOTECMED), Universidad de Valencia, 46100 Burjassot, Spain.
Jose González-MartínezCell Division and Cancer group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.ORCID 0000-0002-3850-6803
Durcia MassoukouUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team Genetics and Development of the Cerebral Cortex, 75014 Paris, France.
Ugo BorelloUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, 56127 Pisa, Italy.ORCID 0000-0001-9812-579X
Frédéric CauseretUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team Genetics and Development of the Cerebral Cortex, 75014 Paris, France.ORCID 0000-0002-0543-4938
Alessandra PieraniUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team Genetics and Development of the Cerebral Cortex, 75014 Paris, France.ORCID 0000-0002-4872-4791
Funding
Agence Nationale de la Recherche ANR-10-IAHU-01Agence Nationale de la Recherche ANR-15-CE16-0003-01Agence Nationale de la Recherche ANR-2011-BSV4-023-01Agence Nationale de la Recherche ANR-20-CE16-0001-01Centre National de la Recherche ScientifiqueFondation Fyssen CH9147Fondation pour la Recherche Médicale DEQ20130326521Fondation pour la Recherche Médicale EQU201903007836Fondation pour la Recherche Médicale SPF20170938863Generalitat Valenciana CDEIGENT/2021/005
6 · The paper itself
Abstract
Brain development requires correct tissue patterning and production of appropriate cell types. Transcription factors play essential roles in these processes, regulating the expression of target genes responsible for the specific features of neuronal subtypes. Cell adhesion molecules are key components of developmental processes that control cell sorting, migration, neurite outgrowth/guidance and synaptogenesis. To date, the link between transcription factors and cell adhesion molecules has been considered unidirectional. Here, we demonstrate that ectopic expression of Dbx1 leads to spatiotemporally restricted increased expression of Pcdh8 and cell aggregation, together with changes in neuronal identity. Surprisingly, ectopic Pcdh8 expression also induces Dbx1 expression, as well as a complete reorganisation of apico-basal polarity and dorso-ventral patterning via Notch signalling. Altogether, our work therefore points to cell adhesion molecules as unexpected, yet important, players in the regulation of cell identity and, in particular, Pcdh8 through its bidirectional interaction with the Dbx1 transcription factor.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Bidirectional interaction between protocadherin 8 and the transcription factor Dbx1 regulates cerebral cortex development. · full record | OpenQuestion