Evidence map›Paper›PMID 41493105›Full record

ArticleeLife2026

Dependence of contextual modulation in macaque V1 on interlaminar signal flow.

Shude Zhu, Yu Jin Oh, Ethan B Trepka, Xiaomo Chen, Tirin Moore

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Brain-like border ownership signals support prediction of natural videos.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Shude ZhuDepartment of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, United States.ORCID https://orcid.org/0000-0002-8674-9607
Yu Jin OhDepartment of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, United States.
Ethan B TrepkaDepartment of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, United States.
Xiaomo ChenDepartment of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, United States.ORCID https://orcid.org/0000-0002-6142-9981
Tirin MooreDepartment of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, United States.ORCID https://orcid.org/0000-0002-3345-2930

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Interaction of Visual and Oculomotor Signals in CortexR01EY014924 · NEI · STANFORD UNIVERSITY · PI MOORE, TIRIN · 2004 to 2024
$7.3M
Large-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and AttentionRF1NS116623 · NINDS · STANFORD UNIVERSITY · PI MOORE, TIRIN, SHENOY, KRISHNA V · 2020 to 2022
$1.8M
Large-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and AttentionR01NS116623 · NINDS · STANFORD UNIVERSITY · PI MOORE, TIRIN, WALLIS, JONI D · 2023 to 2024
$1.0M
Interacting neural mechanisms of selective visual attention and value-based decision-makingR00EY029759 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XIAOMO · 2022 to 2024
$747k
Interaction of Visual and Oculomotor Signals in CortexR56EY014924 · NEI · STANFORD UNIVERSITY · PI MOORE, TIRIN · 2009 to 2009
$398k
Interacting neural mechanisms of selective visual attention and value-based decision-makingK99EY029759 · NEI · STANFORD UNIVERSITY · PI CHEN, XIAOMO · 2019 to 2020
$227k
NEI NIH HHS EY014924NEI NIH HHS EY026877NEI NIH HHS EY029759NEI NIH HHS K99 EY029759NEI NIH HHS P30 EY026877NEI NIH HHS R00 EY029759NEI NIH HHS R01 EY014924NEI NIH HHS R56 EY014924NINDS NIH HHS NS116623NINDS NIH HHS R01 NS116623NINDS NIH HHS RF1 NS116623
6 · The paper itself

Abstract

In visual cortex, neural correlates of subjective perception can be generated by modulation of activity from beyond the classical receptive field (CRF). In macaque V1, activity generated by nonclassical receptive field (nCRF) stimulation involves different intracortical circuitry than activity generated by CRF stimulation, suggesting that interactions between neurons across V1 layers differ under CRF and nCRF stimulus conditions. Using Neuropixels probes, we measured border ownership modulation within large, local populations of V1 neurons. We found that neurons in single columns preferred the same side of objects located outside of the CRF. In addition, we found that cross-correlations between pairs of neurons situated across feedback/horizontal and input layers differed between CRF and nCRF stimulation. Furthermore, independent of the comparison with CRF stimulation, we observed that the magnitude of border ownership modulation increased with the proportion of information flow from feedback/horizontal layers to input layers. These results demonstrate that the flow of signals between layers covaries with the degree to which neurons integrate information from beyond the CRF.

Indexed as

NeuronsVisual CortexVisual PerceptionAnimalsMacaca mulattaPhotic Stimulationcortical feedbackneuroscienceprimary visual cortexrhesus macaquevisual perception

Identifiers

PMID41493105
PMCPMC12774416

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.